Statins may reduce risk of progression of renal cancer

Statins may reduce risk of progression of renal cancer

(HealthDay)—Use of statins is associated with a reduced risk of progression of localized renal cell carcinoma, according to research published in the April issue of The Journal of Urology.

In an effort to assess the effect of statin medications on the progression of the neoplasm, Robert J. Hamilton, M.D., M.P.H., of the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues analyzed data for 2,608 patients receiving surgical treatment for localized renal cell carcinoma.

The researchers found that 27 percent of the patients undergoing surgery for localized renal cell carcinoma were statin users. At a median follow-up of 36 months, statin use was associated with a significant reduction in the risk of progression of localized renal cell carcinoma following surgery (hazard ratio [HR], 0.67; 95 percent confidence interval [CI], 0.47 to 0.96; P = 0.028) and a nonsignificant reduction in overall mortality (HR, 0.89; 95 percent CI, 0.71 to 1.13; P = 0.3). When statin use was modeled as a time-dependent covariate, the reduction in risk of progression of disease was decreased (HR, 0.77; P = 0.12) and the reduction in risk of overall mortality was increased (HR, 0.71; P = 0.002).

"This is the first study to directly examine the association between use at surgery and progression to metastasis or death," the authors write.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Smoking adversely impacts renal cell carcinoma survival

Feb 27, 2014

(HealthDay)—For patients with clear cell renal cell carcinoma, smoking exposure adversely impacts cancer-specific survival and increases the risk of death from another cause, according to a study published ...

Cholesterol drugs might boost kidney cancer survival

May 07, 2013

(HealthDay)—Cholesterol-lowering statin drugs that are taken by millions of Americans might also improve survival from a type of kidney cancer called renal cell carcinoma, a new study suggests.

Statin use at cancer diagnosis linked to lower mortality

Nov 08, 2012

(HealthDay)—For patients with cancer, statin use prior to diagnosis correlates with reduced all-cause and cancer-related mortality, according to a study published in the Nov. 8 issue of the New England Jo ...

Interarm BP difference may up cardiac risk in diabetes

Apr 03, 2014

(HealthDay)—Interarm differences in systolic blood pressure (BP) in patients with diabetes may be associated with an increased risk of cardiovascular morbidity and mortality, according to research published ...

Nephron sparing surgery has excellent lasting outcomes

Nov 19, 2012

(HealthDay)—For patients with bilateral renal masses, nephron sparing surgery (NSS) results in excellent long-term oncological and functional outcomes and survival rates, according to a study published ...

Recommended for you

Early hormone therapy may be safe for women's hearts

4 hours ago

(HealthDay)—Healthy women at low risk of cardiovascular disease may be able to take hormone replacement therapy soon after menopause for a short time without harming their hearts, according to a new study.

Low yield for repeat colonoscopy in some patients

5 hours ago

(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to patients who had no polyps found on adequate examination; however, repeat colonoscopies do benefit patients when the baseline examination was compromised, ...

Cell's recycling center implicated in division decisions

7 hours ago

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified ...

User comments