Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered

In 2009 the influenza pH1N1 virus caused the first flu pandemic in the 21st century. The virus reached Finland in May 2009 and killed more than 50 people in the country. Since 2011 the pH1N1 virus infects Finns mainly during flu epidemics (winter/spring seasons).

Infections with influenza pH1N1 virus vary from asymptomatic to serious complicated illnesses. World Health Organization has recommended Tamiflu for treatment of patients with severe or progressive illness. The disadvantage of this drug is that it targets viral proteins which mutate quickly and the virus develops resistance to it.

The Medical Systems Virology group at FIMM, together with collaborators has recently sequenced genomes of 135 pH1N1 influenza strains isolated from Finnish patients in 2009-2013 and found one Tamiflu-resistant strain from the 2012-2013 epidemic season. The study was published in the Genome Announcements journal and is now available online.

This finding suggests that there could be more resistant strains in upcoming seasons. Therefore, there is a need for the development of new antiviral agents against pH1N1, says Dr. Triin Lakspere.

In another study published this week the group investigated pH1N1 virus-host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block in cell culture.

Importantly, the virus was unable to acquire resistance to host-directed MK2206 in contrast to virus-directed Tamiflu. This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection, Dr. Oxana Denisova says.

add to favorites email to friend print save as pdf

Related Stories

Preparing for Tamiflu-resistant influenza viruses

Dec 09, 2013

Researchers in Umeå and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious consequences in the event ...

Recommended for you

Nanopatch to help WHO battle polio

4 hours ago

The World Health Organisation's (WHO) battle against polio has a new weapon after joining forces with Vaxxas, the biotechnology company responsible for developing revolutionary vaccine delivery method the Nanopatch.

Obama's Ebola response: Is it enough and in time?

8 hours ago

President Barack Obama declared Tuesday that the Ebola epidemic in West Africa could threaten security around the world, and he ordered 3,000 U.S. military personnel to the region in emergency aid muscle ...

First domestic case of chikungunya in Brazil

8 hours ago

Brazil's authorities on Tuesday reported the first domestically contracted cases of the mosquito-borne chikungunya virus, prompting the government to announce it was stepping up attempts to control the disease.

Australia promises $6.4 million to fight Ebola

9 hours ago

Australia announced on Wednesday it will immediately provide an additional 7 million Australian dollars ($6.4 million) to help the international response to the Ebola outbreak in West Africa.

User comments