Combo of tools IDs alcohol use in transplant patients

Combo of tools IDs alcohol use in transplant patients

(HealthDay)—The Alcohol Use Disorders Identification Test for alcohol consumption (AUDIT-c) combined with urinary ethyl glucuronide (uEtG) testing improves the detection of alcohol consumption in liver transplant candidates and recipients, according to a study published online April 2 in Liver Transplantation.

Salvatore Piano, M.D., from the University of Padova in Italy, and colleagues evaluated uEtG, AUDIT-c, serum ethanol, urinary ethanol, carbohydrate-deficient transferrin (CDT), and other indirect markers of in 121 candidates (LTCs) and liver transplant recipients (LTRs).

The researchers found alcohol consumption in 30.6 percent of patients. The strongest marker of alcohol consumption was uEtG (odds ratio, 414.5; P < 0.0001), which showed a more accurate prediction rate of alcohol consumption compared to CDT (area under the receiver operating characteristic curve [AUROC], 0.94 versus 0.63; P < 0.0001) and AUDIT-c (AUROC, 0.94 versus 0.73; P < 0.0001). An even higher accuracy in detecting alcohol consumption was seen with the combination of uEtG with AUDIT-c, compared to the combination of CDT and AUDIT-c (AUROC, 0.98 versus 0.80; P < 0.001). In patients with a negative AUDIT-c, uEtG was the most useful marker for detecting alcohol consumption.

"In conclusion, the association of AUDIT-c and uEtG improves the detection of alcohol consumption in LTCs and LTRs," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Moderate alcohol intake linked to reduced risk of RA

date May 06, 2014

(HealthDay)—There is a modest association between long-term, moderate alcohol consumption and reduced risk of rheumatoid arthritis (RA) in women, according to a study published online April 11 in Arthritis & ...

Many women still report drinking during pregnancy

date Apr 13, 2012

(HealthDay) -- A considerable proportion of women report continuing to drink during pregnancy, but biomarker tests indicate they are drinking at modest levels, according to a study published online April 6 ...

Recommended for you

School scoliosis screening has sustained effectiveness

date May 22, 2015

(HealthDay)—School scoliosis screening can have sustained clinical effectiveness in identifying patients with adolescent idiopathic scoliosis, according to a study published in the May 1 issue of The Sp ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.