Computerized tool cuts risk of prolonged QTc interval

Computerized tool cuts risk of prolonged QT<sub>c</sub> interval

(HealthDay)—Use of a computerized clinical decision support system (CDSS) may reduce the risk of prolonged QTc interval in hospitalized patients at risk for torsades de pointes, according to research published online May 6 in Circulation: Cardiovascular Quality and Outcomes.

James E. Tisdale, Pharm.D., of Purdue University in Indianapolis, and colleagues assessed QTc interval prolongation in admitted to cardiac care units before (1,200 patients) and after (1,200 patients) implementation of the CDSS. QTc interval prolongation was defined as QTc interval >500 ms or increase in QTc of ≥60 ms from baseline.

The researchers found that implementation of the CDSS was independently associated with decreased risk of QTc interval prolongation (adjusted odds ratio [aOR], 0.65; 95 percent confidence interval [CI}, 0.56 to 0.89; P < 0.0001). Use of the CDSS was also associated with decreased prescribing of noncardiac medications known to cause torsades de pointes, including fluoroquinolones and intravenous haloperidol (aOR, 0.79; 95 percent CI, 0.63 to 0.91; P = 0.03).

"A computerized CDSS incorporating a validated risk score for QTc prolongation influences the prescribing of QT-prolonging drugs and reduces the risk of QTc interval prolongation in hospitalized patients with torsades de pointes risk factors," the authors write.

Lilly Endowment Inc. funded the study. One author disclosed financial ties to Eli Lilly and other pharmaceutical companies.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Abnormal EKG can predict death in stroke patients

Mar 20, 2009

People who suffer an ischemic stroke and also have an abnormality in the heart's electrical cycle are at a higher risk of death within 90 days than people who do not have abnormal electrical activity at the time of emergency ...

Interarm BP difference may up cardiac risk in diabetes

Apr 03, 2014

(HealthDay)—Interarm differences in systolic blood pressure (BP) in patients with diabetes may be associated with an increased risk of cardiovascular morbidity and mortality, according to research published ...

Recommended for you

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.