Drug offers huge potential for endometriosis

E2MATE is a steroidal derivative, based upon the sex steroid oestrogen.

A recent clinical study on a drug designed at the University has confirmed its potential in targeting the gynaecological disease endometriosis.

The study entitled 'Synergistic Effects of E2MATE and Norethindrone Acetate on Steroid Sulfatase Inhibition: A Randomized Phase I Proof-of-Principle Clinical Study in Women of Reproductive Age' appeared in the journal Reproductive Sciences earlier this year.

Endometriosis is a benign disease which leads to and infertility. With an estimated 80 million sufferers worldwide, the disease is still poorly understood. The discovery of is critical as most treatments have unpleasant side effects and current therapies have proved inadequate.

E2MATE, also known as PGL2001, was first designed and chemically synthesised in the Medicinal Chemistry Group of our Department of Pharmacy & Pharmacology.

The scientific basis for these trials was founded on a paper published in 2008 by teams at the University and Imperial College, London on Irosustat – another drug originating from the University. The paper showed that the drug, which has reached widespread Phase II cancer trials, has potential for the treatment of .

Commenting on the developments Professor Potter, who was the lead on both the E2MATE and Irosustat projects, said: "The most rewarding thing for any Drug Discovery Group is to see a drug we have designed in the lab overcome the multitude of very difficult hurdles and finally be administered to humans.

"Only the tiniest fraction of all such development candidates ever makes it this far, even in the pharma industry, as they require multidisciplinary teamwork and a multi-million pound budget. I am very encouraged that both our underpinning scientific concepts and the actual itself could translate into clinical benefit for a real unmet need".

More information: "Synergistic Effects of E2MATE and Norethindrone Acetate on Steroid Sulfatase Inhibition: A Randomized Phase I Proof-of-Principle Clinical Study in Women of Reproductive Age." Reproductive Sciences 1933719114522526, first published on March 6, 2014 DOI: 10.1177/1933719114522526

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