Glaucoma risk may be lower with higher folate intake

Glaucoma risk may be lower with higher folate intake

(HealthDay)—The risk of exfoliation glaucoma (EG)/secondary glaucoma (SEG) may be lowered with higher total folate intake, according to a study published in the May issue of JAMA Ophthalmology.

Jae H. Kang, Sc.D., from Brigham & Women's Hospital in Boston, and colleagues analyzed data from a subset of 78,980 women participating in the Nurses' Health Study and 41,221 men participating in the Health Professionals Follow-up Study. Participants were 40 years or older, free of , had completed diet questionnaires, and reported eye examinations.

The researchers found that, in pooled analyses, vitamin B6 and vitamin B12 intake was not associated with EG/SEG risk (P = 0.52 and 0.99, respectively). A trend of reduced risk was detected with higher folate intake, with a relative risk for EG/SEG for the highest folate quintile (≥654 µg/d) of 0.75 (95 percent confidence interval, 0.54 to 1.04; P = 0.02), compared to the lowest quintile. For supplemental folate intake, an association was seen, but no association was seen for dietary folate only (P = 0.003 and 0.64, respectively). There was a modest suggestive inverse association observed for greater frequency of multivitamin use (current multivitamin use of at least six times per week versus nonuse multivariable relative risk, 0.84; 95 percent confidence interval, 0.64 to 1.11; P = 0.06).

"Higher total folate intake was associated with a suggestive lower risk for EG/SEG, supporting a possible causal role of homocysteine in EG/SEG," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Moderate alcohol intake linked to reduced risk of RA

date May 06, 2014

(HealthDay)—There is a modest association between long-term, moderate alcohol consumption and reduced risk of rheumatoid arthritis (RA) in women, according to a study published online April 11 in Arthritis & ...

High folate intake may reduce risk of colorectal cancer

date Jul 05, 2011

Intake of high levels of folate may reduce colorectal cancer risk, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Folate is a water-soluble B vita ...

Long-term dietary fiber intake linked to Crohn's disease

date Dec 02, 2013

(HealthDay)—Long-term intake of dietary fiber is associated with a reduced risk of Crohn's disease (CD), but not ulcerative colitis (UC), according to a study published in the November issue of Gastroenterology.

Recommended for you

Study points way forward for retinal disease gene therapy

date May 03, 2015

Gene therapy for Leber congenital amaurosis (LCA), an inherited disorder that causes vision loss starting in childhood, improved patients' eyesight and the sensitivity of the retina within weeks of treatment. ...

Children's eye injuries from nonpowder guns on the rise

date Apr 27, 2015

Over 3000 children were treated in U.S. emergency departments in 2012 for eye injuries related to paintball guns, airsoft guns, BB guns and pellet guns, which are popular non-powder guns. A new report published ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.