Remember parathyroid hormone as well as vitamin D to assess vitamin's role in diabetes

Combined assessment of parathyroid hormone along with vitamin D may be needed to assess the impact of vitamin D status on sugar metabolism, according to Toronto researchers. Their study is published on-line in Diabetes on May 29, 2014.

The new findings might explain why studies of vitamin D alone have been conflicting and why clinical trials of vitamin D supplementation to improve diabetes have been disappointing, says principal investigator Dr. Ravi Retnakaran. He is a clinician-scientist at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital in Toronto, where he is an endocrinologist in the hospital's Leadership Sinai Centre for Diabetes and associate professor in the Department of Medicine at University of Toronto.

It is well known that, in response to low vitamin D levels, the body increases secretion of (PTH), which is its upstream regulator. Dr. Retnakaran and co-authors show that levels are perturbed only when low vitamin D is accompanied by increased PTH.

Supplementation across the board is not warranted:

The study findings suggest that patients with normal PTH are unlikely to benefit from vitamin D (25-OH-D) supplementation since their glucose handling is normal. Specifically, it may be that glucose metabolism is only adversely affected when circulating 25-OH-D falls to a level that causes PTH to rise, reflecting true functional vitamin D inadequacy.

In other words, not all patients with low vitamin D behave in the same manner. Only those also showing increased PTH appear to be at risk for pre-diabetes and diabetes. For that reason, research on vitamin D in diabetes should focus on patients with low vitamin D and increased PTH.

"Speaking clinically, with these results we can't say that vitamin D supplements should be given to everyone at risk of diabetes who has low vitamin D levels," says Dr. Retnakaran. "We can assess risks associated with low vitamin D only in the context of the person's PTH levels as well."

Observational study of 494 women:

Dr. Retnakaran's team evaluated the prospective associations of 25-OH-D and PTH in 494 postpartum women undergoing serial metabolic characterization.

Notably, 32% of those with pre-diabetes or diabetes at 12 months postpartum had had both vitamin D deficiency and PTH in the highest tertile at three months postpartum. Similarly, on multiple linear regression analyses, vitamin D deficiency or insufficiency with PTH in the highest tertile at three months independently predicted poorer beta-cell function and insulin sensitivity, and increased fasting and two-hour glucose at 12 months postpartum. In contrast, vitamin D deficiency or insufficiency with lower PTH did not predict these outcomes.

These findings support an effect of vitamin D status on glucose homeostasis by demonstrating an independent role of the PTH-vitamin D axis in the development of dysglycemia, insulin resistance, and beta-cell dysfunction.

Most importantly, these data highlight the need for assessment of the entire PTH/25-OH-D axis when studying the effect of vitamin D on glucose metabolism. This concept may partly explain the conflicted literature to date and has implications for future clinical trials examining the impact of vitamin D supplementation on pre-diabetes and .

More information: The study is "Prospective Association of Vitamin D Status with Beta-cell function, Insulin Sensitivity and Glycemia: The Impact of Parathyroid Hormone Status," published in Diabetes.

add to favorites email to friend print save as pdf

Related Stories

Type 1 diabetes: Vitamin D deficiency occurs in an early stage

Feb 27, 2014

Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly ...

Can vitamin D slow heart complications from diabetes?

May 12, 2014

(Medical Xpress)—Researchers at Washington University School of Medicine in St. Louis are evaluating whether vitamin D can slow the development of cardiovascular problems in African-Americans with diabetes. ...

Low Vitamin D may not be a culprit in menopause symptoms

Apr 16, 2014

A new study from the Women's Health Initiative (WHI) shows no significant connection between vitamin D levels and menopause symptoms. The study was published online today in Menopause, the journal of The North American Menopa ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.