In resting brains, researchers see signs of schizophrenia

by Bill Hathaway
In resting brains, Yale researchers see signs of schizophrenia
Colored areas highlight significant variations in activity of brains in people with schizophrenia not engaged in tasks when compared to control subjects. Credit: Yale University

(Medical Xpress)—In an advance that increases hopes of finding biological markers for schizophrenia, Yale researchers have discovered widespread disruption of signals while the brain is at rest in those suffering from the disabling neuropsychiatric disease.

The Yale team used fMRI scans and created a that simulates brain activity to discover the disruptions in global signaling—or patterns of while the brain is not involved in any particular task.

Previously, many researchers had thought that the overall brain activity at rest was mostly "background noise" and not clinically important, said Alan Anticevic, assistant professor in psychiatry at the Yale School of Medicine and senior author of the study, reported online May 5 in the Proceedings of the National Academy of Sciences.

"To our knowledge these results provide the first evidence that global whole-brain signals are altered in schizophrenia, calling into question the standard removal of this signal in clinical neuroimaging studies," Anticevic said.

These novel results have vital and broad implications for neuroimaging, as the search for neuropsychiatric biomarkers that could lead to early intervention and improved patient outcomes remains a prominent focus outlined by the National Institute of Mental Health.

More information: "Altered global brain signal in schizophrenia," by Genevieve J. Yang et al. PNAS, 2014: www.pnas.org/cgi/doi/10.1073/pnas.1405289111

add to favorites email to friend print save as pdf

Related Stories

Researchers find rare genetic cause of Tourette syndrome

Jan 09, 2014

A rare genetic mutation that disrupts production of histamine in the brain is a cause of the tics and other abnormalities of Tourette syndrome, according to new findings by Yale School of Medicine researchers.

Recommended for you

'Chatty' cells help build the brain

20 hours ago

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate ...

'Trigger' for stress processes discovered in the brain

Nov 27, 2014

At the Center for Brain Research at the MedUni Vienna an important factor for stress has been identified in collaboration with the Karolinska Institutet in Stockholm (Sweden). This is the protein secretagogin ...

New research supporting stroke rehabilitation

Nov 26, 2014

Using world-leading research methods, the team of Dr David Wright and Prof Paul Holmes, working with Dr Jacqueline Williams from the Victoria University in Melbourne, studied activity in an area of the brain ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

thought_less_50
4 / 5 (2) May 05, 2014
This is amazing news.
Sinister1812
not rated yet May 06, 2014
This is amazing news.


It's not really a cure though.
matteo72
1.3 / 5 (3) May 06, 2014
This is not science, but quack science
There is no evidence whatsoever that schizophrenia has biological basis
There is no straight evidence whatsoever about what even schizophrenia is
Like Prof. Szasz once said:
"If you talk to God you are a Good Christian, if God talks to you you are a schizophrenic"
Schizophrenia is probably a concept invented by the multinationals of pharma to sell more "cures"
It is a pity that this news" is listed as science

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.