In resting brains, researchers see signs of schizophrenia

May 5, 2014 by Bill Hathaway
In resting brains, Yale researchers see signs of schizophrenia
Colored areas highlight significant variations in activity of brains in people with schizophrenia not engaged in tasks when compared to control subjects. Credit: Yale University

(Medical Xpress)—In an advance that increases hopes of finding biological markers for schizophrenia, Yale researchers have discovered widespread disruption of signals while the brain is at rest in those suffering from the disabling neuropsychiatric disease.

The Yale team used fMRI scans and created a that simulates brain activity to discover the disruptions in global signaling—or patterns of while the brain is not involved in any particular task.

Previously, many researchers had thought that the overall brain activity at rest was mostly "background noise" and not clinically important, said Alan Anticevic, assistant professor in psychiatry at the Yale School of Medicine and senior author of the study, reported online May 5 in the Proceedings of the National Academy of Sciences.

"To our knowledge these results provide the first evidence that global whole-brain signals are altered in schizophrenia, calling into question the standard removal of this signal in clinical neuroimaging studies," Anticevic said.

These novel results have vital and broad implications for neuroimaging, as the search for neuropsychiatric biomarkers that could lead to early intervention and improved patient outcomes remains a prominent focus outlined by the National Institute of Mental Health.

Explore further: Study explores how brain disruption may foster schizophrenia

More information: "Altered global brain signal in schizophrenia," by Genevieve J. Yang et al. PNAS, 2014:

Related Stories

Study explores how brain disruption may foster schizophrenia

September 26, 2012

(Medical Xpress)—A team led by Yale researchers has used pharmacological neuroimaging and computational modeling to examine large-scale functional organization in the human brain. Their novel approach has yielded important ...

Recommended for you

New insights on how cocaine changes the brain

November 25, 2015

The burst of energy and hyperactivity that comes with a cocaine high is a rather accurate reflection of what's going on in the brain of its users, finds a study published November 25 in Cell Reports. Through experiments conducted ...

Can physical exercise enhance long-term memory?

November 25, 2015

Exercise can enhance the development of new brain cells in the adult brain, a process called adult neurogenesis. These newborn brain cells play an important role in learning and memory. A new study has determined that mice ...

Umbilical cells help eye's neurons connect

November 24, 2015

Cells isolated from human umbilical cord tissue have been shown to produce molecules that help retinal neurons from the eyes of rats grow, connect and survive, according to Duke University researchers working with Janssen ...

Brain connections predict how well you can pay attention

November 24, 2015

During a 1959 television appearance, Jack Kerouac was asked how long it took him to write his novel On The Road. His response – three weeks – amazed the interviewer and ignited an enduring myth that the book was composed ...


Adjust slider to filter visible comments by rank

Display comments: newest first

4 / 5 (2) May 05, 2014
This is amazing news.
not rated yet May 06, 2014
This is amazing news.

It's not really a cure though.
1.3 / 5 (3) May 06, 2014
This is not science, but quack science
There is no evidence whatsoever that schizophrenia has biological basis
There is no straight evidence whatsoever about what even schizophrenia is
Like Prof. Szasz once said:
"If you talk to God you are a Good Christian, if God talks to you you are a schizophrenic"
Schizophrenia is probably a concept invented by the multinationals of pharma to sell more "cures"
It is a pity that this news" is listed as science

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.