Triple negative breast cancer, ethnicity, and socioeconomic status

May 12, 2014
Mammograms showing a normal breast (left) and a cancerous breast (right). Credit: Wikipedia.

An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative (TN) breast cancer, a subtype that has a poorer prognosis. The analysis also found that Asian/Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so-called human epidermal growth factor receptor 2 (HER2)–overexpressing breast cancer. The study appears early online in Breast Cancer Research and Treatment.

Triple-negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. Triple-negative breast cancers tend to grow and spread more quickly than most other types of , and a lack of these receptors limits treatment options.

Previous studies have indicated that non-Hispanic blacks and Hispanics were more likely to be diagnosed with triple negative breast cancer than non-Hispanic whites. Some studies have suggested that the higher odds of breast cancer subtypes with unfavorable prognoses in minority racial/ethnic groups could be explained by differences in socioeconomic status. However, these studies were limited by their small and incomplete sampling.

For the current study, scientists led by Helmneh Sineshaw, M.D., MPH, analyzed data from 260,174 breast cancer cases recorded in the National Cancer Data Base (NCDB), a national hospital-based cancer registry database jointly sponsored by the American College of Surgeons and the American Cancer Society. The analysis showed that patients with had higher proportions of triple negative breast cancers than did patients with high or moderate socioeconomic status. However, even after controlling for socioeconomic status, the difference remained: were 1.84 times as likely to be diagnosed with the triple negative subtype. The researchers also found that compared with white women, Asian/Pacific Islander women had higher odds of presenting with HER2-overexpressing breast cancer, a difference that was also observed at every level of socioeconomic status.

"The excess odds of triple negative breast cancer in blacks compared to whites were remarkably similar, about 80% higher, in each socioeconomic group," said Dr. Sineshaw. "That consistent increase suggests factors other than differences in play a strong role in the excess odds seen in black . Further studies are needed to identify those factors."

More information: Association of Race/Ethnicity, Socioeconomic Status, and Breast Cancer Subtypes in the National Cancer Data Base (2010-2011); H Sineshaw, M Gaudet; E Ward; W Flanders; C Desantis; C Lin; A Jemal. Breast Cancer Res Treat DOI: 10.1007/s10549-014-2976-9

Related Stories

Recommended for you

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.