No apparent link between chronic cerebrospinal venous insufficiency and MS

There appears to be no link between chronic cerebrospinal venous insufficiency and multiple sclerosis (MS), according to new research published in CMAJ (Canadian Medical Association Journal).

In 2009, Dr. Paolo Zamboni postulated that chronic cerebrospinal venous insufficiency is a cause of MS, an inflammatory disease of the central nervous system that affects people in northern climates in particular. Published evidence has not been able to find a link to MS, and no one has been able replicate his findings. Several recent studies have shown an association between ultrasound-diagnosed chronic cerebrospinal venous insufficiency and MS but results vary widely.

Using and magnetic resonance venography, researchers undertook a study to explore the validity of the theory that chronic cerebrospinal venous insufficiency and MS are linked. They enrolled 120 patients with MS and 60 healthy controls. A high percentage of patients (58%) and controls (63%) met one or more proposed ultrasound criteria that would help diagnose chronic cerebrospinal venous insufficiency although there were no differences seen between groups.

"We detected no link between chronic cerebrospinal venous insufficiency and ," writes Dr. Fiona Costello, departments of Clinical Neurosciences and Surgery, University of Calgary, Calgary, Alberta, with coauthors. They cite concerns over the diagnosis of chronic cerebrospinal venous insufficiency.

"We also identified several methodologic concerns that challenge the validity of the criteria used to define chronic cerebrospinal , and in turn we dispute the authenticity of this diagnosis."

More information: Paper: www.cmaj.ca/lookup/doi/10.1503/cmaj.131431

add to favorites email to friend print save as pdf

Related Stories

FDA issues warning on controversial MS treatment

May 10, 2012

(HealthDay) -- Doctors and patients need to be aware of the potential risk of injuries and death associated with an experimental treatment for multiple sclerosis called liberation therapy, the U.S. Food and ...

New study debunks controversial MS theory

Aug 14, 2013

There is no evidence that impaired blood flow or blockage in the veins of the neck or head is involved in multiple sclerosis, says a McMaster University study.

Recommended for you

The hidden burden of dengue fever in West Africa

9 hours ago

Misdiagnosis of febrile illnesses as malaria is a continuing problem in Africa. A new study shows that in Ghana, dengue fever is circulating in urban areas and going undiagnosed. The authors of the study hope to use the findings ...

Teenager with stroke symptoms actually had Lyme disease

9 hours ago

A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease. The highly unusual case presentation was published ...

Understanding lung disease in aboriginal Australians

11 hours ago

A new study has confirmed that Aboriginal Australians have low forced vital capacity—or the amount of air that can be forcibly exhaled from the lungs after taking the deepest breath possible. The finding may account for ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.