Big data analytics can predict risk of metabolic syndrome

Research published today in the American Journal of Managed Care demonstrates that analysis of patient records using state-of-the-art data analytics can predict future risk of metabolic syndrome. More than a third of the U.S. population has metabolic syndrome, a condition that can lead to chronic heart disease, stroke and diabetes. These conditions combine to account for almost 20 percent of overall health care costs in the U.S. The study was conducted by Aetna and GNS Healthcare Inc. (GNS), a leading provider of big data analytics products and services in health care.

"This study demonstrates how integration of multiple sources of patient data can help predict patient-specific medical problems," said lead author Dr. Gregory Steinberg, head of clinical innovation at Aetna Innovation Labs. "We believe the personalized clinical outreach and engagement strategies, informed by data from this study, can help improve the health of people with and reduce the associated costs."

"The breakthrough in this study is that we are able to bring to light hyper-individualized patient predictions, including quantitatively identifying which individual patients are most at risk, which syndrome factors are most likely to push that patient past a threshold, and which interventions will have the greatest impact on that individual," said Colin Hill, co-founder and CEO of GNS. "The GNS automated data analytics platform paired with Aetna's deep clinical expertise produced these results on extremely large datasets in just three months, a testament to the ability of both groups."

GNS analyzed data from nearly 37,000 members of one of Aetna's employer customers who had voluntarily participated in screening for metabolic syndrome. The data analyzed included medical claims records, demographics, pharmacy claims, lab tests and biometric screening results over a two-year period. For this study, the Aetna and GNS teams utilized two distinct analytical models:

  • A claims-based-only model to predict the probability of each of the five metabolic syndrome factors occurring for each study subject.
  • A second model based on both claims and biometric data to predict whether each study subject is likely to get worse, improve or stay the same for each metabolic syndrome factor.

Both analytical models predicted future risk of metabolic syndrome on both a population and an individual level, with ROC/AUC (receiver operating characteristic/area under the curve) varying from 0.80 and 0.88. The researchers were able to develop detailed risk profiles for individual participants, enabling a deep understanding of exactly which combination of the five metabolic syndrome factors each of the study subjects exhibit and are at risk for developing. For every Aetna member whose data was used in the study, the researchers used a scale that measures the percentage risk that individuals have of exhibiting each of the five metabolic syndrome factors. For example, in an individual patient who exhibited two of the five risk factors, researchers could predict which third factor is the most likely to develop.

The analytical models also helped identify individual variable impact on risk associated with adherence to prescribed medications, as well as adherence to routine, scheduled outpatient doctor visits. A scheduled, outpatient visit with a primary care physician lowers the one-year probability of having metabolic syndrome in nearly 90 percent of individuals. In addition, the study found that improving waist circumference and blood glucose yielded the largest benefits on patients' subsequent risk and medical costs.

add to favorites email to friend print save as pdf

Related Stories

BMI thresholds predict metabolic syndrome in teens

Jan 29, 2014

(HealthDay)—The U.S. Centers for Disease Control and Prevention and FITNESSGRAM (FGram) body mass index (BMI) thresholds are predictive of metabolic syndrome in U.S. adolescents, according to a study published ...

New study finds taste preferences impact health

Feb 14, 2013

Individuals who have a high preference for sweets and a high aversion to bitter flavors may be at an increased risk of developing metabolic syndrome, according to a new study in the Journal of Food Science, published by the ...

Metabolic syndrome may cause kidney disease

Aug 19, 2011

Metabolic syndrome comprises a group of medical disorders that increase people's risk of diabetes, heart disease, stroke, and premature death when they occur together. A patient is diagnosed with the syndrome when he or she ...

Recommended for you

Health law enrollment now 7.3M

3 minutes ago

The Obama administration says 7.3 million people have signed up for subsidized private health insurance under the health care law—down from 8 million reported earlier this year.

ASTRO issues second list of 'Choosing wisely' guidelines

25 minutes ago

(HealthDay)—The American Society for Radiation Oncology (ASTRO) has released a second list of five radiation oncology-specific treatments that should be discussed before being prescribed, as part of the ...

Bill Gates says progress made on new super-thin condom

1 hour ago

Billionaire philanthropist Bill Gates said Thursday progress is being made on developing a "next-generation" ultra-thin, skin-like condom that could offer better sexual pleasure, help population control and ...

User comments