Circadian misalignment may impact diabetes risk

Circadian misalignment may impact diabetes risk

(HealthDay)—Circadian misalignment decreases insulin sensitivity and increases inflammation, and is independent of sleep loss in men, according to a study published in the June issue of Diabetes.

Rachel Leproult, Ph.D., from the University of Chicago, and colleagues conducted a parallel group design study involving 26 adults. The authors sought to examine whether the misalignment of that typically occurs in shift work involves intrinsic adverse metabolic effects, independently of . The interventions involved three inpatient days with 10-hour bedtimes, followed by eight inpatient days with to five hours and fixed nocturnal bedtimes (circadian alignment), or with delayed bedtimes on four of the eight days with sleep restriction (circadian misalignment).

The researchers found that daily total sleep time was nearly identical in the aligned and misaligned conditions during the intervention (four hours 48 minutes versus four hours 45 minutes, respectively). Insulin sensitivity decreased significantly in both groups after sleep restriction, with no compensatory increase in insulin secretion; inflammation increased in both groups. The reduction in and increase in inflammation both doubled in male participants exposed to circadian misalignment compared with those who maintained regular nocturnal bedtimes.

"Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Repeated use of antibiotics linked to diabetes risk

date Mar 25, 2015

Repeated use of some types of antibiotics may put people at increased risk of developing type-2 diabetes by possibly altering their gut bacteria, according to a large observational study published today in the European Jo ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.