Clinical guidelines issued for drug-induced liver injury

June 18, 2014
Clinical guidelines issued for drug-induced liver injury

(HealthDay)—Herbal and dietary supplements (HDS) account for an increasing proportion of idiosyncratic drug-induced liver injury (DILI), according to practice guidelines published online June 17 in the American Journal of Gastroenterology.

Naga P. Chalasani, M.D., from the Indiana University School of Medicine in Indianapolis, and colleagues reviewed the evidence and developed clinical guidelines for idiosyncratic DILI. The recommendations are intended for use by physicians and other .

The guidelines focus on diagnostic evaluation and causality assessment, noting that DILI remains a diagnosis of exclusion. In addition, the researchers discuss risk factors, prognosis, and management of hepatotoxicity. Many HDS can cause DILI; among DILI cases, HDS are the second most common cause. The most common types of HDS implicated in causing disease are supplements used for body building and weight loss. Current safety regulations differ for HDS and for conventional prescription medications, with no requirement for premarketing safety analysis of HDS. Patients and providers should be aware of this, as well as being aware of the potential for HDS to cause . Current causality approaches are not well suited to HDS hepatotoxicity.

"A lot of consumers have a preconceived notion that if it's a natural product, it must be safe. But that is not necessarily the case," a coauthor said in a statement. "Most of these products are not well-regulated and have very little oversight."

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Herbal and dietary supplements can adversely affect prescribed drugs says extensive review

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Dietary supplements can cause liver injury, warns expert

October 29, 2012

Dose-dependent (acetaminophen) and idiosyncratic drug-induced liver injuries (DILI) are the leading cause of acute liver failure in the United States and are responsible for approximately 50 percent of all reported cases.

Drug-induced liver injury is on the rise

June 26, 2013

More people are being affected by drug-induced liver injury (DILI) than ever before, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. This type of liver injury ...

Recommended for you

Zika in fetal brain tissue responds to a popular antibiotic

November 30, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, ...

Zika and glaucoma linked for first time in new study

November 30, 2016

A team of researchers in Brazil and at the Yale School of Public Health has published the first report demonstrating that the Zika virus can cause glaucoma in infants who were exposed to the virus during gestation.

Flu forecasts successful on neighborhood level

November 30, 2016

Scientists at Columbia University's Mailman School of Public Health developed a computer model to predict the onset, duration, and magnitude of influenza outbreaks for New York City boroughs and neighborhoods. They found ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.