Clinical guidelines issued for drug-induced liver injury

June 18, 2014
Clinical guidelines issued for drug-induced liver injury

(HealthDay)—Herbal and dietary supplements (HDS) account for an increasing proportion of idiosyncratic drug-induced liver injury (DILI), according to practice guidelines published online June 17 in the American Journal of Gastroenterology.

Naga P. Chalasani, M.D., from the Indiana University School of Medicine in Indianapolis, and colleagues reviewed the evidence and developed clinical guidelines for idiosyncratic DILI. The recommendations are intended for use by physicians and other .

The guidelines focus on diagnostic evaluation and causality assessment, noting that DILI remains a diagnosis of exclusion. In addition, the researchers discuss risk factors, prognosis, and management of hepatotoxicity. Many HDS can cause DILI; among DILI cases, HDS are the second most common cause. The most common types of HDS implicated in causing disease are supplements used for body building and weight loss. Current safety regulations differ for HDS and for conventional prescription medications, with no requirement for premarketing safety analysis of HDS. Patients and providers should be aware of this, as well as being aware of the potential for HDS to cause . Current causality approaches are not well suited to HDS hepatotoxicity.

"A lot of consumers have a preconceived notion that if it's a natural product, it must be safe. But that is not necessarily the case," a coauthor said in a statement. "Most of these products are not well-regulated and have very little oversight."

Several authors disclosed financial ties to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Dietary supplements can cause liver injury, warns expert

October 29, 2012

Dose-dependent (acetaminophen) and idiosyncratic drug-induced liver injuries (DILI) are the leading cause of acute liver failure in the United States and are responsible for approximately 50 percent of all reported cases.

Drug-induced liver injury is on the rise

June 26, 2013

More people are being affected by drug-induced liver injury (DILI) than ever before, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. This type of liver injury ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.