Deppression with atypical features associated with obesity

June 4, 2014

Major depressive disorder (MDD) with atypical features (including mood reactivity where people can feel better when positive things happen in life, increased appetite or weight gain) appears to be associated with obesity.

MDD has tremendous public health impact worldwide. Obesity is another burden for . Understanding the mechanisms underlying the association between MDD and obesity is important.

The study (which had 5.5 years of follow-up) included 3,054 residents (average age nearly 50 years) from Lausanne, Switzerland. The main outcomes were changes in (BMI), waist circumference and during follow-up.

At baseline, 7.6 percent of participants met the criteria for MDD. Among the participants with MDD, about 10 percent had atypical and melancholic episodes, 14 percent had atypical episodes, 29 percent had melancholic episodes and 48 percent had unspecified episodes. MDD with atypical features was associated during the follow-up period with a higher increase in adiposity in terms of BMI, incidence of obesity and in both sexes, as well as fat mass in men. The study suggests the higher BMI increase in participants with MDD with atypical features also was not temporary and persisted after remission of the depressive episode.

"For the clinician, the atypical subtype deserves particular attention because this subtype is a strong predictor of adiposity. Accordingly, the screening of atypical features and, in particular, increased appetite in individuals with depression is crucial. The prescription of appetite-stimulating medication should be avoided in these patients and dietary measures during depressive episodes with atypical features are advocated." Aurélie M. Lasserre, M.D., of Lausanne University Hospital, Switzerland, and colleagues wrote in their JAMA Psychiatry article.

More information: JAMA Psychiatry. Published online June 4, 2014. DOI: 10.1001/jamapsychiatry.2014.411

Related Stories

Depression linked to reduced temporofrontolimbic coupling

June 6, 2012

(HealthDay) -- Patients with remitted major depressive disorder (MDD) have reduced guilt-selective temporofrontolimbic coupling between the right superior anterior temporal lobe (ATL) and subgenual cingulate cortex and adjacent ...

Depression second leading cause of global disability burden

November 5, 2013

A study published this week in PLOS Medicine reports the most recent and comprehensive estimates on how much death and disability is attributable to depression, both world-wide and in individual countries and regions.

Recommended for you

Can a new drug brown the fat and trim the obese person?

May 28, 2015

New research has found that a variant of a drug used to treat pulmonary arterial hypertension prompts weight loss in obese mice. Among mice fed a high-fat diet, those who did not get the medication became obese while medicated ...

Changing stem cell structure may help fight obesity

February 17, 2015

The research, conducted at Queen Mary University of London (QMUL), found that a slight regulation in the length of primary cilia, small hair-like projections found on most cells, prevented the production of fat cells from ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.