Hormone-disrupting activity of fracking chemicals worse than initially found

Many chemicals used in hydraulic fracturing, or fracking, can disrupt not only the human body's reproductive hormones but also the glucocorticoid and thyroid hormone receptors, which are necessary to maintain good health, a new study finds. The results were presented Monday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

"Among the chemicals that the industry has reported using most often, all 24 that we have tested block the activity of one or more important hormone receptors," said the study's presenting author, Christopher Kassotis, a PhD student at the University of Missouri, Columbia. "The high levels of hormone disruption by endocrine-disrupting chemicals (EDCs) that we measured, have been associated with many poor health outcomes, such as infertility, cancer and birth defects."

Hydraulic fracturing is the process of injecting numerous chemicals and millions of gallons of water deep underground under high pressure to fracture hard rock and release trapped natural gas and oil. Kassotis said spills of wastewater could contaminate surface and ground water.

In earlier research, this group found that water samples collected from sites with documented fracking spills in Garfield County, Colorado, had moderate to high levels of EDC activity that mimicked or blocked the effects of the female hormones (estrogens) and the male hormones (androgens) in human cells. However, water in areas away from these gas-drilling sites showed little EDC activity on these two reproductive hormones.

The new study extended the analysis to learn whether high-use fracking chemicals changed other key besides the estrogen and androgen receptors. (Receptors are proteins in cells that the hormone binds to in order to perform its function.) Specifically, the researchers also looked at the receptor for a female reproductive hormone, progesterone, as well as those for glucocorticoid—a hormone important to the immune system, which also plays a role in reproduction and fertility—and for thyroid hormone. The latter hormone helps control metabolism, normal brain development and other functions needed for .

Among 24 common fracking chemicals that Kassotis and his colleagues repeatedly tested for EDC activity in human cells, 20 blocked the estrogen receptor, preventing estrogen from binding to the receptor and being able to have its natural biological response, he reported. In addition, 17 chemicals inhibited the androgen receptor, 10 hindered the progesterone receptor, 10 blocked the glucocorticoid receptor and 7 inhibited the receptor.

Kassotis cautioned that they have not measured these chemicals in local water samples, and it is likely that the high concentrations tested would not show up in drinking water near drilling. However, he said mixtures of these chemicals act together to make their -disrupting effects worse than any one chemical alone, and tested drinking water normally contains mixtures of EDCs.

"We don't know what the adverse health consequences might be in humans and animals exposed to these chemicals," Kassotis said, "but infants and children would be most vulnerable because they are smaller, and infants lack the ability to break down these chemicals."

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eachus
not rated yet Aug 16, 2014
Another case of 'scare' headlines connected to otherwise sensible research. The chemicals put down-hole in fracking are mostly things you can buy at the grocery store. (Well grocery stores sometimes sell sand in winter around here. And they sell plenty of detergents.)

The mix that comes back up though is a real witches brew. The natural gas isn't too bad, but the petroleum contains benzene and other aromatic hydrocarbons. Once that oil is captured and sent off to a refinery, it will be made into (relatively) safe products--like detergents. Studies of failures to contain fracking wastewater are usually addressed at the disposal of wastewater that comes up entrained in the gas. Yes, it needs to be disposed of safely, and this is usually done by pumping it down dry holes, or wells that have been exhausted.

Anyway, if you drank a quart of the fracking mixture, it would just taste real bad. If you drank even a couple swallows of the oil and gas mix that comes up? Hospital time.

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