Immune response affects sleep and memory

Sickness-induced insomnia is common because of link between brain and immune system

Fighting off illness- rather than the illness itself- causes and affects memory, a new study has found.

University of Leicester biologist Dr Eamonn Mallon said a common perception is that if you are sick, you sleep more.

But the study, carried out in flies, found that sickness induced insomnia is quite common.

Dr Mallon said: "Think about when you are sick. Your sleep is disturbed and you're generally not feeling at your sharpest. Previously work has been carried out showing that being infected leads to exactly these behaviours in .

"In this paper we show that it can be the immune system itself that can cause these problems. By turning on the immune system in flies artificially (with no infection present) we reduced how long they slept and how well they performed in a .

"This is an interesting result as these connections between the brain and the immune system have come to the fore recently in medicine. It seems to be because the two systems speak the same chemical language and often cross-talk. Having a model of this in the fly, one of the main systems used in will be a boost to the field.

"The key message of this study is that the , sleep and memory seem to be intimately linked. Medicine is beginning to study these links between the brain and the immune system in humans. Having an easy to use insect model would be very helpful."

More information: "Immune stimulation reduces sleep and memory ability in Drosophila melanogaster" - PeerJ, Eamonn B. Mallon, Akram Alghamdi, Robert T.K. Holdbrook, Ezio Rosato, DOI: 10.7717/peerj.434

add to favorites email to friend print save as pdf

Related Stories

Unusual comparison nets new sleep loss marker

May 03, 2013

(Medical Xpress)—For years, Paul Shaw, PhD, a researcher at Washington University School of Medicine in St. Louis, has used what he learns in fruit flies to look for markers of sleep loss in humans.

Recommended for you

A novel therapy for sepsis?

8 hours ago

A University of Tokyo research group has discovered that pentatraxin 3 (PTX3), a protein that helps the innate immune system target invaders such as bacteria and viruses, can reduce mortality of mice suffering ...

Cellular protein may be key to longevity

Sep 15, 2014

Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions ...

Gut bacteria tire out T cells

Sep 15, 2014

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Me ...

User comments