No link found between soy food and endometrial cancer risk, say researchers

Researchers have found no evidence of a protective association between soy food and endometrial cancer risk, says a new study published (18 June) in BJOG: An International Journal of Obstetrics and Gynaecology.

Soy foods are an almost exclusive dietary source of isoflavones, a plant-derived estrogen. Some studies have highlighted their potential cancer protective properties, however, research looking at the link to endometrial cancer has been inconsistent.

The study defined short IPI as time from the immediate preceding birth to subsequent birth of the index pregnancy of <6 months, 6 to <12 months, and 12 to <18 months. Researchers categorized the women with short IPIs into two groups, IPI less than 12 months and IPI 12-18 months, comparing them to women who were considered to have an optimal IPI of 18 months or more.

The food questionnaire specifically asked about the consumption of 8 soy food items such as miso soup, tofu and soymilk. Researchers then looked at the total dietary intake of genistein and daidzein, different types of isoflavones.

The women were divided into three groups according to the intake of soy foods and isoflavones. In the follow up, 112 women were diagnosed with endometrial cancer.

Women consuming more isoflavones were older, less likely to be current smokers, alcohol and regular coffee drinkers, and more likely to have a history of diabetes. They also had a higher dietary intake of fruit and vegetables.

Looking specifically at tofu, miso soup and soy food, the researchers found no association with endometrial cancer. Neither higher consumption of total soy foods nor isoflavones were associated with the risk of endometrial cancer after adjustment for factors such as age, alcohol consumption, smoking, BMI, menopausal status, coffee intake and number of deliveries.

Dr Motoki Iwasaki, Epidemiology Division, Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan and co-author said:

"Our study found that intake of soy and isoflavones were not associated with the risk of endometrial .

"Although the incidence of is much lower in Asian countries, the incidence rate has been increasing. We also know that the consumption of soy foods among Japanese people is very high.

"We need further studies with a greater number of cases to verify these findings and add to the research base."

John Thorp, BJOG Deputy-Editor-in-Chief, said:

"This large population-based study found no evidence of a protective association of or isoflavone intake and previous studies have been inconsistent.

"Confirmation of these results needs further investigation and larger more diverse studies."

More information: Budhathoki S, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsuganea S for the JPHC Study Group. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG 2014; DOI: 10.1111/1471-0528.12853

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