Lithium may protect against cartilage decline in osteoarthritis

June 27, 2014
Lithium may protect against cartilage decline in osteoarthritis

(HealthDay)—Lithium reduces catabolic events in interleukin-1 β (IL-1β)-treated human articular chondrocytes and protects against cartilage degradation in IL-1β-treated mouse knee joints, according to a study published in the May issue of Arthritis & Rheumatology.

Takeshi Minashima, Ph.D., from New York University, and colleagues treated human articular chondrocytes with lithium chloride (LiCl) and IL-1β. Real-time polymerase chain reaction then determined expression levels of catabolic genes. Additionally, the activation of NF-KB was determined using luciferase reporter assays. Immunoblot analysis of total cell lysates determined the activities of MAPKs and the STAT-2 signaling pathway.

The researchers found that LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-KB, p38 MAPK, and STAT-3 signaling in IL-1β-treated articular chondrocytes. LiCl also directly inhibited IL-6-stimulated activation of STAT-3 signaling. Eight weeks after osteoarthritis induction surgery, the severity of cartilage destruction in LiCl-treated mouse knee joints or in LiCl-treated mouse femoral head explants after IL-1β treatment were markedly reduced versus in vehicle-treated joints or explants.

"LiCl reduced catabolic events in IL-1β-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1β-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA," the authors write.

Explore further: Vitamin D analogs modulate immunity in psoriasis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Vitamin D analogs modulate immunity in psoriasis

March 9, 2012

(HealthDay) -- Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin (TSLP) and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

A treatment for obesity-associated asthma

December 16, 2013

(Medical Xpress)—Research conducted at Boston Children's Hospital indicates that obesity might cause asthma via factors in the immune system and suggests a new way of treating asthma in obese people—who often respond ...

Recommended for you

New strategy for treating arthritis discovered

November 25, 2015

Arthritis patients could one day benefit from a novel form of medicine, according to researchers at Queen Mary University of London (QMUL). Their early study indicates that arthritic cartilage, previously thought to be impenetrable ...

Team finds gene that confirms existence of psoriatic arthritis

February 5, 2015

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.