Post-op kidney risk reduced in 'off-pump' patients

by Paul Mayne

(Medical Xpress)—Among patients undergoing coronary artery bypass graft (CABG) surgery, those who were not put on a heart-lung machine (off-pump) had a reduced risk of postoperative kidney injury compared to patients who were (on-pump), although there was no evidence of better preserved kidney function by one year after surgery, according to a Western-led study published in the June 4 issue of the Journal of the American Medical Association.

Led by Schulich School of Medicine & Dentistry professor Dr. Amit X. Garg, the study is being released early online to coincide with the European Renal Association-European Dialysis and Transplant Association Congress.

Schulich colleague Dr. Richard Novick was also among the paper's co-authors.

Up to 30 percent of develop mild or moderate acute kidney injury after cardiac surgery. The effects of mild or moderate acute kidney injury on long-term kidney are not clear, and it has not been proven in any trial that an intervention that reduces the risk of acute kidney injury better preserves longer-term kidney function, according to background information in the study.

The international team of researchers conducted a substudy of the Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularization Study (CORONARY), which enrolled patients undergoing CABG surgery and who were randomized to receive the off-pump or on-pump procedure. The substudy included 2,932 patients (from 63 sites in 16 countries).

The researchers found less acute kidney injury with off-pump (17.5 per cent) versus on-pump (20.8 per cent) CABG surgery within 30 days. In a subgroup analysis, the absolute risk reduction of acute kidney injury with off-pump versus on-pump CABG surgery was greater in those with chronic kidney disease compared with those without chronic kidney disease.

There was no significant difference between the 2 groups in the loss of kidney function at one year (off-pump, 17.1 per cent; on-pump, 15.3 per cent).

"The findings emphasize proof is needed to claim an intervention that reduces the of mild acute kidney injury better preserves long-term for the group that received it," the authors wrote. "This has implications for the development, testing, and use of interventions designed solely to prevent the degrees of acute kidney injury observed in CORONARY, and in determining acceptable adverse effects and costs of such interventions."

More information: Garg AX, Devereaux PJ, Yusuf S, et al. "Kidney Function After Off-Pump or On-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial." JAMA. 2014;311(21):2191-2198. DOI: 10.1001/jama.2014.4952.

add to favorites email to friend print save as pdf

Related Stories

Open heart surgery for kidney disease patients

May 17, 2012

One type of open heart surgery is likely safer than the other for chronic kidney disease (CKD) patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Personalized fluid levels cuts acute kidney injury

May 28, 2014

(HealthDay)—A new fluid protocol is safe and effective in preventing contrast-induced acute kidney injury in patients undergoing cardiac catheterization, according to a study published in the May 24 issue ...

Recommended for you

Guidelines presented for diagnosing focal liver lesions

13 hours ago

(HealthDay)—Focal liver lesions (FLLs) are mostly benign, and can be diagnosed based on knowledge of their presentation, associated clinical and laboratory features, and natural history, according to clinical ...

Factors tied to neck, back pain improvement identified

17 hours ago

(HealthDay)—Observational registry-based research can inform patients and physicians about prognosis for subacute or chronic neck or low back pain, according to a study published in the Aug. 1 issue of ...

User comments