Does psychostimulant use increase cardiovascular risk in children with ADHD?

Psychostimulant use to treat children and adolescents with attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide, and the evaluation of the cardiovascular safety of stimulant medication used in treatment has been a recent topic of concern. The results of the first nationwide study of the cardiovascular safety of stimulants in children and adolescents are published in Journal of Child and Adolescent Psychopharmacology (JCAP).

Søren Dalsgaard, MD, PhD, and coauthors, Aarhus University and iPSYCH (Denmark), University of Southern Denmark, Hospital of Telemark (Norway), and Yale University School of Medicine (New Haven, CT), conducted a prospective study of more than 700,000 children in Denmark; 8,300 had ADHD. The researchers compared stimulant use and cardiovascular events in the entire population and in children with ADHD and found a small but statistically significant risk associated with treatment; they also report on the relationship between specific stimulant dose and risk of a . Their results appear in the article "Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder—A Nationwide Prospective Cohort Study."

"This study confirms the small but real risk we have understood for some time through prior reports and clinical experience," says Harold S. Koplewicz, MD, Editor-in-Chief of Journal of Child and Adolescent Psychopharmacology and President, Child Mind Institute, New York, NY. "But Dalsgaard et al.'s excellent design and the robust sample size make it abundantly clear that treating clinicians cannot ignore existing guidelines concerning the assessment of cardiac risk prior to treatment and monitoring key vital signs during the course."

More information: The article is available free on the JCAP website.

Related Stories

ADHD treatment associated with lower smoking rates

date May 12, 2014

Treating attention deficit hyperactivity disorder (ADHD) with stimulant medication may reduce smoking risk, especially when medication is taken consistently, according to an analysis led by researchers at ...

Stimulant, antipsychotic combo improves aggressive behavior

date Jan 24, 2014

(HealthDay)—For children with attention deficit/hyperactivity disorder (ADHD) and aggressive disorders, the addition of risperidone to a combination of parent training and psychostimulant is associated with moderate improvement ...

Recommended for you

Simple classroom measures may reduce the impact of ADHD

date Jul 01, 2015

Children with Attention Deficit Hyperactivity Disorder (ADHD) may be successfully supported in classrooms through strategies that do not involve drugs, new research has indicated. These children are typically ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.