Suboptimal usage of proton pump inhibitors common

June 11, 2014
Suboptimal usage of proton pump inhibitors common

(HealthDay)—For patients with gastroesophageal reflux disease (GERD), those who receive a proton pump inhibitor (PPI) prescription from gastroenterologists are more likely to be optimal users and have better symptom control, according to a study published in the June issue of the American Journal of Gastroenterology.

Imran Sheikh, M.D., from Case Western Reserve University in Cleveland, and colleagues surveyed 1,959 patients with GERD at five clinics to assess dosing patterns and symptom control in over-the-counter (OTC) and prescription PPI users. Participants were surveyed regarding GERD diagnosis, use of PPIs, information on dosing, demographics, and Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS).

The researchers found that 31 percent of participants used PPIs for GERD. Of these, 32 percent purchased OTC PPIs, while 31 and 37 percent, respectively, received prescriptions from gastroenterologists and . Optimal use was reported by 71 percent of those prescribed PPIs by gastroenterologists, compared with 47 percent of those receiving prescriptions from primary care providers and 39 percent of consumers (both P < 0.001). Patients prescribed PPIs by gastroenterologists had significant better GSAS symptom, frequency, and severity scores (all P < 0.001, compared with provider and consumer). Patients using PPIs optimally had significantly better GSAS symptom, frequency, and severity scores, compared with those taking PPIs suboptimally or excessively (all parameters, P < 0.001).

"Patients receiving prescription PPI from a gastroenterologist are more likely to be optimal users with better symptom control," the authors write.

Explore further: Heartburn controlled with step down to once daily therapy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Heartburn controlled with step down to once daily therapy

February 27, 2012

(HealthDay) -- The majority of gastroesophageal reflux disease (GERD) patients who take twice-daily proton pump inhibitor (PPI) therapy, are able to successfully step down to management of heartburn with a daily dose of dexlansoprazole ...

Many patients keep using PPIs after negative GERD test

June 5, 2012

(HealthDay) -- Nearly half of patients continue to use proton pump inhibitors (PPIs) even after pH studies confirm that they do not have gastroesophageal reflux disease (GERD), and most do not recall being instructed to stop ...

Prescription problems for vets on reflux drug

February 20, 2013

U.S. veterans diagnosed with gastroesophageal reflux disease (GERD) are frequently prescribed doses of proton pump inhibitors (PPIs), such as omeprazole (commonly known by brand names such as Prilosec), that are much higher ...

Recommended for you

Ebola virus mutations may help it evade drug treatment

September 11, 2015

Genetic mutations called "escape variants" in the deadly Ebola virus appear to block the ability of antibody-based treatments to ward off infection, according to a team of U.S. Army scientists and collaborators. Their findings, ...

Study finds viral protein that causes dengue shock

September 9, 2015

Scientists at the University of California, Berkeley, have identified a key culprit responsible for the fluid loss and resulting shock that are the hallmark of severe - and potentially fatal - dengue virus infections.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.