New treatment option in development for individuals with food allergy

Credit: Mary Ann Liebert, Inc., publishers

For some children an allergic reaction to common foods such as milk, eggs, or peanuts can cause an anaphylactic reaction. At present no effective treatment for food allergy exists, and strict dietary avoidance of known food triggers is the only preventive option available. Ongoing trials are exploring options for oral immunotherapy (OIT) for desensitization in the treatment of Immunoglobulin E (IgE)-mediated food allergy, as described in a Review article in Pediatric Allergy, Immunology, and Pulmonology.

In "Oral Immunotherapy for Treatment of Immunoglobulin E-Mediated Food Allergy: The Transition to Clinical Practice," Giovanni Pajno, MD and coauthors, University of Messina, Italy and Nova Southeastern University, Fort Lauderdale, FL, review the current state of OIT research for the induction of tolerance in individuals with food allergies. While early trials with OIT appear promising, rigorous, multicenter, randomized, placebo-controlled studies are needed to address remaining questions regarding optimal formulation, dosing, and duration for the induction of tolerance in affected patients.

"Oral immunotherapy for the treatment of IgE-mediated remains experimental with a number of unanswered questions," says Editor-in-Chief Mary Cataletto, MD, Professor of Clinical Pediatrics, State University of New York at Stony Brook (Stony Brook, NY) and practicing pediatric pulmonologist at Winthrop University Hospital. "However, it offers the potential for not only a life-saving but life-changing therapy for individuals with food allergies."

More information: The article is available free on the Pediatric Allergy, Immunology, and Pulmonology website.

add to favorites email to friend print save as pdf

Related Stories

As one food allergy resolves, another may develop

Mar 02, 2014

Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. A new study by pediatric allergy experts suggests that health care providers ...

Recommended for you

Could trophoblasts be the immune cells of pregnancy?

Dec 18, 2014

Trophoblasts, cells that form an outer layer around a fertilized egg and develop into the major part of the placenta, have now been shown to respond to inflammatory danger signals, researchers from Norwegian University of ...

Moms of food-allergic kids need dietician's support

Dec 18, 2014

Discovering your child has a severe food allergy can be a terrible shock. Even more stressful can be determining what foods your child can and cannot eat, and constructing a new diet which might eliminate entire categories ...

Multiple allergic reactions traced to single protein

Dec 17, 2014

Johns Hopkins and University of Alberta researchers have identified a single protein as the root of painful and dangerous allergic reactions to a range of medications and other substances. If a new drug can ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.