Drinking coffee, smoking may protect against cholangitis

July 8, 2014
Drinking coffee, smoking may protect against cholangitis

(HealthDay)—Coffee consumption and smoking might protect against the development of primary sclerosing cholangitis (PSC), according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

Ina Marie Andersen, from the Oslo University Hospital in Norway, and colleagues distributed a questionnaire to 240 patients with PSC as well as 245 randomly chosen individuals from the Norwegian Bone Marrow Donor Registry ().

The researchers found that a lower proportion of patients with PSC were daily coffee drinkers than control subjects, both currently (76 versus 86 percent; odds ratio [OR], 0.52; P = 0.006) and at the age of 18 years (35 versus 49 percent; OR, 0.58; P = 0.003). Differences among men mainly accounted for these associations. In patients, 20 percent were ever (current or former) daily smokers, compared with 43 percent of control subjects (OR, 0.33; P < 0.001). There was an association between ever daily smoking before PSC diagnosis and older age at diagnosis (42 versus 32 years; P < 0.001). Among females, fewer patients ever used hormonal contraception versus controls (51 versus 85 percent; P < 0.001). There was a strong correlation in women between increasing number of children before the diagnosis of PSC and increasing age at diagnosis (P < 0.001).

"Coffee consumption and smoking might protect against development of PSC," the authors write.

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winthrom
not rated yet Jul 08, 2014
For the uninformed, the disease "primary sclerosing cholangitis (PSC)" is defined:

http://www.mayocl...20029446

I see a correlation without explanation yet.

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