A Crohn's disease-associated gene expression profile and microbial community

Crohn's and other inflammatory bowel diseases (IBDs) can be painful and debilitating. There are no known cures for these diseases, but the symptoms can be managed. It is widely thought that IBDs develop as a result of an individual's genetic make-up, their gut microbiota, and environmental cues, though it is not fully understood how these factors promote IBDs.

A new study in the Journal of Clinical Investigation identifies a specific gene expression profile and microbial community associated with Crohn's disease. Lee Denson and colleagues at Cincinnati Children's Hospital Medical Center compared the intestines of healthy patients to pediatric Crohn's disease patients.

Crohn's disease patients had altered expression of 2 genes, DUOX2 and APOA1, as well as a distinct microbial community. Furthermore, APOA1 expression and microbial abundance could be used to predict clinical outcomes in Crohn's disease patients.

More information: Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature, J Clin Invest. DOI: 10.1172/JCI75436

Related Stories

Recommended for you

Time to move Lyme Disease Awareness Month to April?

date 3 hours ago

The month of May brings many things, among them Mother's Day, tulips, and Lyme Disease Awareness campaigns. But according to Dr. Richard S. Ostfeld, a disease ecologist at the Cary Institute of Ecosystem ...

An explanation of wild birds' role in avian flu outbreak

date 4 hours ago

Wild birds are believed to be behind the first major widespread outbreak of bird flu in the United States. The H5N2 virus has cost Midwestern turkey and chicken producers almost 13 million birds since early March, including ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.