Progression of dysglycemia in youth similar to adults

Progression of dysglycemia in youth similar to adults

(HealthDay)—For obese adolescents, glucose sensitivity deteriorates progressively across the spectrum of glucose tolerance, according to a study published online June 19 in Diabetes.

Sara F. Michaliszyn, Ph.D., from the University of Pittsburgh Medical Center, and colleagues describe oral glucose tolerance test (OGTT)-modeled β-cell function and incretin effect in 255 obese adolescents (173 with normal glucose tolerance, 48 with impaired glucose tolerance, and 34 with type 2 diabetes). An established mathematical model yielding β-cell glucose sensitivity, rate sensitivity, and was used to derive β-cell function parameters. The ratio of the OGTT β-cell glucose sensitivity to the two-hour hyperglycemic clamp β-cell glucose sensitivity was calculated as the incretin effect.

The researchers found that β-cell glucose sensitivity was 30 and 65 percent lower in youth with impaired glucose tolerance and type 2 diabetes, respectively, compared with normal glucose tolerance. In type 2 diabetes, rate sensitivity was 40 percent lower. Incretin effect was 32 and 38 percent lower for youth with impaired glucose tolerance and type 2 , respectively, compared with normal glucose tolerance, when faced with similar changes in glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in response to oral glucose.

"We conclude that glucose sensitivity deteriorates progressively in obese youth across the spectrum of in association with impairment in incretin effect without reduction in GLP-1 or GIP, similar to that seen in adult dysglycemia," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Insulin sensitivity normally highest after breakfast

Oct 26, 2012

(HealthDay)—In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes ...

Sucralose affects response to oral glucose load in obese

Jul 02, 2013

(HealthDay)—For obese adults who do not use non-nutritive sweetener (NNS), sucralose affects the glycemic and insulin responses to an oral glucose load, according to a study published online April 30 in ...

Genetic risk score linked to increased risk of diabetes

Jul 30, 2013

(HealthDay)—A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according ...

Vitamin D does not improve glycemic control in prediabetes

Jul 03, 2014

(HealthDay)—Supplementation with vitamin D does not appear to improve glycemic indices or cardiovascular risk factors in individuals with prediabetes, according to research published online June 19 in Diabetes Ca ...

Recommended for you

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments