Insulin resistance ups T2D risk, independent of BMI

Insulin resistance ups T2D risk, independent of BMI

(HealthDay)—A genetic score for insulin resistance is associated with lower body mass index (BMI) and with incident type 2 diabetes (T2D) even among individuals of normal weight, according to a study published online June 19 in Diabetes.

Robert A. Scott, Ph.D., from the University of Cambridge in the United Kingdom, and colleagues examined the correlations of genetic scores with euglycemic-hyperinsulinemic clamp- and oral glucose tolerance test-based measures of and secretion in up to 18,565 individuals. They also examined the correlation between genetic variants and T2D risk among 8,124 , overweight, and obese incident T2D cases.

The researchers found that the insulin resistance score correlated with lower , as measured by M/I value (P = 0.004). Significant correlations were seen for the insulin resistance score with lower BMI and gluteofemoral fat-mass, and with higher alanine transaminase and gamma-glutamyltransferase. In leaner individuals, the secretion score was more strongly associated with T2D (Pinteraction = 0.001), but the association between insulin resistance score and T2D did not differ among BMI- or waist-strata (Pinteraction > 0.31).

"While insulin resistance is often considered secondary to obesity, the association of the insulin resistance score with lower BMI and adiposity and with incident T2D even among individuals of normal weight highlights the role of insulin resistance and ectopic fat distribution in T2D, independently of body size," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Circulating MicroRNAs linked to type 2 diabetes

Feb 07, 2014

(HealthDay)—Circulating microRNAs (miRNAs) are associated with type 2 diabetes (T2D), and their levels vary with insulin action, according to a study published online Jan. 29 in Diabetes Care.

Insulin resistance cut-off established from clamp data

Apr 23, 2012

(HealthDay) -- Cut-offs for predicting insulin resistance based on hyperinsulinemic-euglycemic clamp data and routinely measured clinical and biochemical variables have been determined, according to a study ...

Fruit, veggie intake has no impact on insulin resistance

Nov 01, 2013

(HealthDay)—For individuals at high risk of cardiovascular disease, increased consumption of fruits and vegetables has no impact on insulin resistance, according to a study published in the Oct. 15 issue ...

ECO: Pistachio nut consumption cuts insulin resistance

Jun 01, 2014

(HealthDay)—Consumption of pistachio nuts is associated with decreased insulin resistance in individuals with prediabetes, according to a study presented at the annual European Congress on Obesity, held ...

Recommended for you

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments