Novel methods may help stem cells survive transplantation into damaged tissues

Credit: 2014, Mary Ann Liebert, Inc., publisher

Stem cells offer much promise for treating damaged organs and tissues, but with current transplantation approaches stem cell survival is poor, limiting their effectiveness. New methods are being developed and tested to improve the survival and optimize their therapeutic function after transplantation, as described in a Review article in BioResearch Open Access.

In the article 'Preconditioning Stem Cells for In Vivo Delivery,' Sébastien Sart, Ecole Polytechnique (Palaiseau, France) and Teng Ma and Yan Li, Florida State University (Tallahassee) examine the leading strategies for preconditioning prior to transplantation to prepare them for the environment often found in damaged tissue. Preconditioning methods might include exposing stem cells to microenvironments characterized by reduced oxygen levels, heat shock, and oxidative stress, creating three-dimensional stem cell aggregates or microtissues, and using hydrogels in which to embed or encapsulate the cells.

"This article provides an extensive review of the current methods of stem cell preconditioning for transplantation," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "It also highlights the employed to do this."

More information: The article is available free on the BioResearch Open Access website.

Related Stories

Inner ear stem cells hold promise for restoring hearing

date Jun 21, 2014

Spiral ganglion cells are essential for hearing and their irreversible degeneration in the inner ear is common in most types of hearing loss. Adult spiral ganglion cells are not able to regenerate. However, ...

Recommended for you

Study identifies Ebola virus's Achilles' heel

date 2 hours ago

An international team including scientists from Albert Einstein College of Medicine of Yeshiva University and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) has identified the ...

Stem cell therapy for inherited skin blistering

date 4 hours ago

Promising results from a trial of a new stem-cell based therapy for a rare and debilitating skin condition have been published in the Journal of Investigative Dermatology. The therapy, involving infusions of ste ...

Simple recipe to make sensory hair cells in the ear

date 4 hours ago

Scientists at the Molecular Medicine Institute in Lisbon, Portugal, and at the University College London Ear Institute, United Kingdom, have developed a simple and efficient protocol to generate inner ear hair cells, the ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.