Mouse study suggests natural birth may strengthen the immune system

A number of studies suggest that children delivered by Caesarean section have a different intestinal flora than children delivered by natural birth. But it is still unknown why this is the case and what it means for the immune system. University of Copenhagen researchers decided to scrutinise the impact of birth on the development of the immune system in a study of newborn mouse pups.

The study shows that pups delivered by Caesarean section had developed a lower number of cells that strengthen the immune system, says Camilla Hartmann Friis Hansen, Assistant Professor at the Department of Veterinary Disease Biology. The findings have recently been published in Journal of Immunology.

Mother's bacteria may be important

Newborns delivered by natural birth are exposed to more bacteria from the mother than those delivered by Caesarean section. According to a research hypothesis called the hygiene hypothesis, the 's immune system in this way learns to distinguish between its own harmless molecules and foreign molecules. In the experiment, pups delivered by Caesarean section showed a lower number of cells of a type that plays an important role in preventing reactive immune cells from responding to molecules from the body itself, from the diet and from harmless intestinal bacteria. Autoimmune diseases such as type 1 diabetes, Chrohn's disease and allergy are precisely characterised by an over-reaction by the immune system.

The researchers then looked for signs of development of type 1 diabetes in pups delivered by Caesarean section, but found none. The next step is therefore to study whether the pups are predisposed to other and then to test the theses in .

The experiments on mice may give us an idea of what would be interesting to study in more detail in clinical trials, so that in the long term, we may be able to develop methods for strengthening the in newborns who are predisposed to autoimmune diseases, says Professor Axel Kornerup Hansen, Department of Veterinary Disease Biology.

add to favorites email to friend print save as pdf

Related Stories

Gluten-free diet reduces risk of type 1 diabetes in mice

May 08, 2014

New experiments on mice show, that mouse mothers can protect their pups from developing type 1 diabetes by eating a gluten-free diet. According to preliminary studies by reseachers at the University of Copenhagen, ...

Caesarean babies more likely to develop diabetes

Aug 26, 2008

Babies delivered by Caesarean section have a 20 per cent higher risk than normal deliveries of developing the most common type of diabetes in childhood, according to a study led by Queen's University Belfast.

Recommended for you

Study discovers means to free immune system to destroy cancer

22 hours ago

Research led by Paulo Rodriguez, PhD, an assistant research professor of Microbiology, Immunology & Parasitology at LSU Health New Orleans' Stanley S. Scott Cancer Center, has identified the crucial role an inflammatory protein ...

Commensal bacteria help orchestrate immune response in lung

Sep 11, 2014

Studies in mice demonstrate that signals from the bacteria that harmlessly—and often beneficially—inhabit the human gastrointestinal tract boost the immune system's ability to kill a major respiratory pathogen, Klebsiella pn ...

User comments