mTORC pathway involved in antiphospholipid sx vasculopathy

mTORC pathway involved in antiphospholipid sx vasculopathy
The mammalian target of rapamycin complex pathway seems to be involved in antiphospholipid syndrome-associated vascular lesions, according to a study published in the July 24 issue of the New England Journal of Medicine.

(HealthDay)—The mammalian target of rapamycin complex (mTORC) pathway seems to be involved in antiphospholipid syndrome-associated vascular lesions, according to a study published in the July 24 issue of the New England Journal of Medicine.

Guillaume Canaud, M.D., Ph.D., from Université Paris Descartes, and colleagues examined the molecular pathways involved in the vasculopathy of antiphospholipid syndrome. Double immunostaining was used to assess pathway activation in mTORC. In addition, the nature of cell proliferation was assessed in the vessels of patients with primary or secondary antiphospholipid syndrome nephropathy.

The researchers found that patients with antiphospholipid syndrome nephropathy exhibited indications of mTORC pathway activation in the of proliferating intrarenal vessels. Immunoglobulin G antibodies from patients with antiphospholipid syndrome stimulated mTORC in cultured through the phosphatidylinositol 3-kinase-AKT pathway. Compared with patients with antiphospholipid antibodies who required transplantation and were not receiving sirolimus, those who were receiving sirolimus had no recurrence of vascular lesions and decreased vascular proliferation on biopsy. Seventy percent of patients treated with sirolimus had a functioning renal allograft at 144 months after transplantation, compared with 11 percent of untreated patients. The of autopsy specimens from patients with catastrophic antiphospholipid syndrome had evidence of mTORC activation.

"Our results suggest that the mTORC pathway is involved in the vascular lesions associated with the ," the authors write.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Cause of ageing remains elusive

20 hours ago

A report by Chinese researchers in the journal Nature a few months ago was a small sensation: they appeared to have found the cause for why organisms age. An international team of scientists, headed by the ...

Newly discovered bacterial defence mechanism in the lungs

21 hours ago

A new study from Karolinska Institutet presents a previously unknown immunological mechanism that protects us against bacterial infections in the lungs. The study is being published in the American Journal of Respiratory an ...

User comments