Predicting the outcome of hepatitis C virus treatment

Millions of people throughout the world are infected with hepatitis C virus (HCV), which can lead to cirrhosis of the liver and cancer. Directly acting antiviral agents inhibit viral proteins and have been used to successfully treat HCV. Unfortunately, antiviral therapy fails in some patients, resulting in a relapse of HCV.

A study published in the Journal of Clinical Investigation identifies a marker that can identify patients likely to have an HCV relapse after . Shyamasundaran Kottilil and colleagues at the NIH evaluated the immune response of HCV-infected individuals treated with . Treated patients that had increased expression of type I interferon were more likely to remain HCV-free. Patients unable to maintain a type I interferon response were more likely to have an HCV relapse.

This study provides a potential marker to identify patients prone to HCV relapse. Moreover, these results suggest that type I interferon treatment in at-risk patients merits future study.

More information: Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome, J Clin Invest. DOI: 10.1172/JCI75938

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Researchers ferret out a flu clue

4 hours ago

Research that provides a new understanding as to why ferrets are similar to humans is set to have major implications for the development of novel drugs and treatment strategies.

In the battle against Ebola, a double-layer solution

7 hours ago

When working with Ebola patients, protective gear works, but removing it can be harrowing. Seeking to protect health care workers from the precarious nature of taking off soiled gloves, Cornell students have ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.