New prognostic factors may be useful in staging melanoma

July 16, 2014
New prognostic factors may be useful in staging melanoma
New prognostic factors may be useful in predicting survival in patients with thin melanoma, according to research published online July 7 in the Journal of Clinical Oncology.

(HealthDay)—New prognostic factors may be useful in predicting survival in patients with thin melanoma, according to research published online July 7 in the Journal of Clinical Oncology.

Andrea Maurichi, M.D., of the Istituto Nazionale dei Tumori in Milan, and colleagues analyzed data for 2,243 patients with thin . The authors sought to explore new and construct a nomogram for predicting survival in individual patients.

The researchers found that the worst prognosis for thin melanoma was associated with age older than 60 years, Breslow thickness greater than 0.75 mm, mitotic rate (MR) of 1 or higher, presence of ulceration, presence of lymphovascular invasion (LVI), and regression of 50 percent or greater. All of these factors, except age and regression, were significantly associated with sentinel node positivity. Independent predictors of survival, including age, MR, ulceration, LVI, regression, and sentinel node status, were used to construct a nomogram for predicting overall survival at 12 years.

"Our findings suggest including LVI and regression as new prognostic factors in the melanoma staging system," the authors write. "The appears useful for risk stratification in clinical management and for recruiting patients to clinical trials."

Explore further: Tumor-Infiltrating lymphocyte grade IDs melanoma survival

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Tumor-Infiltrating lymphocyte grade IDs melanoma survival

June 20, 2012

(HealthDay) -- Tumor-infiltrating lymphocyte (TIL) grade is an independent predictor of melanoma-specific survival and sentinel lymph node (SLN) status in patients with localized primary cutaneous melanoma, according to a ...

Lymphovascular invasion is independent predictor of survival

July 29, 2012

(HealthDay) -- In patients with invasive breast cancer, lymphovascular invasion (LVI) is a strong and independent predictor of both breast cancer-specific survival (BCSS) and distant metastasis-free survival (DMFS), according ...

Nonsentinel lymph nodes key factor in melanoma prognosis

August 2, 2013

(HealthDay)—Nonsentinel lymph node (NSLN) positivity is a significant prognostic factor in patients with stage III melanoma, associated with shorter overall and disease-specific survival, according to research published ...

Study compares survival for treatments of uncommon eye cancer

June 17, 2014

In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but no improvement in overall ...

Recommended for you

Shape of tumor may affect whether cells can metastasize

April 28, 2016

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.