Retinal regeneration in zebrafish (w/ Video)

by Keith Hautala

University of Kentucky biologist Ann Morris is studying retinal regeneration in zebrafish to find ways to combat human eye diseases.

The small, minnow-like fish have eyes that develop in a way very similar to humans. Unlike humans, however, have the ability to regenerate following an injury. Diseases of the retina are a leading cause of blindness in older adults.

"With zebrafish the embryos develop outside the mother, and they are completely transparent. And development occurs very rapidly," Morris said. "So we can study the process of the development of eye under the light microscope in a dish, and it only takes a couple days to happen."

How is it that zebrafish can regenerate retinal cells and we can't? Morris says the answer is suspended between two distinct possibilities.

"One is that everybody had the ability to regenerate, and that ability in certain lineages was eventually lost," she said. "So as mammals evolved, somehow they lost the ability to regenerate , but perhaps all the mechanism is still there, in their genome, so we need to find those switches and turn it back on.

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"The other possibility though is that certain vertebrates evolved that ability whereas others didn't. And so it's possible that mammals can't regenerate neurons because they just don't have that mechanism. I happen to believe it's probably more of the former, that some of those abilities are there and they're latent and we have to discover how to reactivate them.

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