Research offers new hope for treatment of rare genetic disease

by Charlotte Anscombe

New research by experts at The University of Nottingham could offer new clues for the treatment of a rare genetic disease.

TRAPS (TNF Receptor Associated Periodic Syndrome) was first identified in Nottingham more than 30 years ago and causes periodic, spontaneous flares of fever, rashes, muscle pains and other symptoms without any other apparent cause.

The new research, published in The European Journal of Immunology, provides the most complete picture to date of the changes that happen inside the cells of TRAPS patients that trigger the attacks of fever and inflammation that occur in the .

Dr Lucy Fairclough, of the University's School of Life Sciences, was among a team of immunology researchers who led the study. She said: "TRAPS has a serious effect on the lives of its sufferers—imagine having symptoms similar to flu, with those symptoms appearing every few weeks and possibly lasting several weeks, and this happens life-long."

"Fortunately, the research that has led to improved understanding of TRAPS has also led to better therapies for the disease that can greatly improve the quality of life for patients. However, these therapies are treating the consequences of the disease rather than the processes inside cells of the body that are driving the disease.  In the latest study we provide the most complete picture to date of the changes that happen inside the cells of TRAPS patients that trigger the attacks of fever and inflammation.  This opens new avenues for trying to block these disease-causing processes at their source, with the hope of better therapies for TRAPS."

TRAPS was first described in a research article published in The Quarterly Journal of Medicine in 1982 by Williamson and colleagues who worked at Nottingham University Hospitals NHS Trust and the University's Medical School.

At the time, these doctors gave the disease the name 'Familial Hibernian Fever' because all patients were members of the same family originating from Ireland (Hibernia being the Roman name for Ireland).

In the late 1990s, it was found that this is a genetic disease affecting what's called TNF Receptor 1 and the name of the disease was changed to TRAPS in recognition of this fact. It is now known that TRAPS affects thousands of people in many different families around the world.

This latest study, which also involved academics from Mansoura University in Egypt, the German Cancer Research Centre in Heidelberg, Germany, and Nottingham University Hospitals NHS Trust, opens new avenues for trying to block these disease-causing cell changes at their source, with the hope of better therapies for not only for TRAPS but for other diseases of this type.

add to favorites email to friend print save as pdf

Related Stories

Stink bug traps may increase damage to tomato fruits

Mar 25, 2014

The invasive brown marmorated stink bug (Halyomorpha halys) is an important pest of fruits and vegetables. To counter them, some home gardeners use pheromone-baited traps that are designed to attract, trap, and kill them. ...

Expelled DNA that traps toxins may backfire in obese

Jun 18, 2013

(Medical Xpress)—The body's most powerful immune cells may have a radical way of catching their prey that could backfire on people who are overweight and others at risk for cancer, diabetes and chronic ...

Cells' energy factories linked to damaging inflammation

Jan 31, 2011

Scientists have discovered that molecules called reactive oxygen species (ROS) produced by the energy factories, or mitochondria, in cells, may play a role in a rare inherited disorder in which uncontrolled inflammation damages ...

Recommended for you

Study unlocks basis of key immune protein's two-faced role

Nov 26, 2014

A Brigham and Women's Hospital-led team has identified a long sought-after partner for a key immune protein, called TIM-3, that helps explain its two-faced role in the immune system—sometimes dampening it, other times stimulating ...

Profilin can induce severe food-allergic reactions

Nov 25, 2014

(HealthDay)—Profilins are complete food allergens in food-allergic patient populations that are exposed to high levels of grass pollen, according to a study published in the December issue of Allergy.

Structured education program beneficial for anaphylaxis

Nov 21, 2014

(HealthDay)—A structured education intervention improves knowledge and emergency management for patients at risk for anaphylaxis and their caregivers, according to a study published online Nov. 19 in Allergy.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.