Wake-up call for more research into cell metabolism

More scientific research into the metabolism of stromal support cells and immune cells – and the role of the metabolism of these cell types in the development of diseases – could open new therapeutic avenues for diabetes, inflammatory conditions and cancer. That was the conclusion of a review article by scientists from VIB and KU Leuven in the leading journal Nature.

Prof. Peter Carmeliet: "Consider the review article a sort of wake-up call. The metabolism of cancer cells has been examined in minute detail for decades now in order to facilitate new oncology treatments, whilst the metabolic research into other important cells such as the stromal and has not received the scientific attention that it deserves. Metabolic studies into these cells could provide new targets for the treatment of, for example, and diabetes."

Cell metabolism

Stromal cells are the support cells of the body. One important type of support cell is the endothelial cell, which lines the inner wall of . Blood vessels transport oxygen and nutrients to cells. Immune cells attack harmful bacteria and viruses in order to remove them from the body. Each type of cell requires different types of "food" in order to convert this into the energy and nutrients required to allow the cells to do their work. This is called cell metabolism. We now know that – in the case of cancer, diabetes and inflammatory diseases – the supply and processing of this "food" to endothelial cells and other support cells is abnormal. This allows endothelial cells to form new blood vessels (also called angiogenesis) in an excessive manner and causes tumors to grow aggressively due to the fact that the supply of cell nutrients is cranked up.

In the interests of the patients

Cancer research of the past 15 to 20 years has focused almost exclusively on the metabolism of cancer cells. However, the focus on has placed efforts to study other important cells such as endothelial cells and immune cells on the back burner. This is a shortcoming according to Peter Carmeliet, Bart Ghesquière, Brian W. Wong and Anna Kuchnio in their review article that will be published in Nature on 10 July. All the evidence seems to indicate that thorough research into the of , and immune could result in new treatment options not only for cancer, but also for diabetes and inflammatory diseases.

This will also be necessary to improve the current cancer treatments. Indeed, angiogenesis inhibitors are being used to combat cancer, but their success is limited by the fact that cancer patients become resistant to these drugs. Strategies that will paralyze the blood vessels by taking away their energy and building blocks appear very promising. With their ardent plea in Nature they hope that – in the interests of the patients – the scientific focus over the coming years will shift to this sub-section of medical and pharmacological research.

More information: Bart Ghesquière et al., Metabolism of stromal and immune cells in health and disease, Nature, 2014.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Growing a blood vessel in a week

14 hours ago

The technology for creating new tissues from stem cells has taken a giant leap forward. Three tablespoons of blood are all that is needed to grow a brand new blood vessel in just seven days. This is shown ...

Testing time for stem cells

17 hours ago

DefiniGEN is one of the first commercial opportunities to arise from Cambridge's expertise in stem cell research. Here, we look at some of the fundamental research that enables it to supply liver and pancreatic ...

Team finds key signaling pathway in cause of preeclampsia

Oct 23, 2014

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause ...

Rapid test to diagnose severe sepsis

Oct 23, 2014

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.

User comments