Weight loss over two years predicts reduced diabetes risk

Weight loss over two years predicts reduced diabetes risk

(HealthDay)—Weight loss over two years is associated with reduced diabetes incidence and improvement in cardiometabolic risk factors, according to a study published online July 14 in Diabetes Care.

Linda M. Delahanty, R.D., from Massachusetts General Hospital in Boston, and colleagues examined measures of in relation to incident and cardiometabolic risk factors. Data were collected for 1,000 participants in the Diabetes Prevention Program lifestyle intervention arm. They analyzed nine measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling. The authors sought to examine predictors of incident diabetes and improvement in cardiometabolic risk factors.

The researchers found that weight loss in the first six months was protective of diabetes (hazard ratio, 0.94 per kg; P < 0.01) and cardiometabolic risk factors (P < 0.01); however, long-term weight loss (from zero to two years) was the strongest predictor of decreased incidence of diabetes (hazard ratio, 0.90 per kg; P < 0.01) and cardiometabolic risk factor improvement (for example, fasting glucose; P < 0.01). Per participant, weight cycling ranged from zero to six times and correlated positively with incident diabetes (hazard ratio, 1.33; P < 0.01), fasting glucose (P = 0.02), homeostatic model assessment insulin resistance (P = 0.04), and systolic blood pressure (P = 0.01). The effect of weight cycling was significant for diabetes risk (hazard ratio, 1.22; P = 0.03), but not for cardiometabolic traits, after adjustment for baseline weight.

"Two-year weight loss was the strongest predictor of reduced and improvements in cardiometabolic traits," the authors write.

Pharmaceutical, nutrition, and exercise industries donated materials, equipment, or medicines and/or supported the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Nonalcoholic fatty liver disease linked to CKD in T1DM

Apr 09, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published ...

Liraglutide augments weight loss in pre-type 2 diabetes

Aug 15, 2013

(HealthDay)—For patients at high risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), liraglutide in additional to calorie restriction is associated with more weight loss and improvements ...

Insulin resistance ups T2D risk, independent of BMI

Jul 07, 2014

(HealthDay)—A genetic score for insulin resistance is associated with lower body mass index (BMI) and with incident type 2 diabetes (T2D) even among individuals of normal weight, according to a study published ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

16 hours ago

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.