Weight loss over two years predicts reduced diabetes risk

July 22, 2014
Weight loss over two years predicts reduced diabetes risk

(HealthDay)—Weight loss over two years is associated with reduced diabetes incidence and improvement in cardiometabolic risk factors, according to a study published online July 14 in Diabetes Care.

Linda M. Delahanty, R.D., from Massachusetts General Hospital in Boston, and colleagues examined measures of in relation to incident and cardiometabolic risk factors. Data were collected for 1,000 participants in the Diabetes Prevention Program lifestyle intervention arm. They analyzed nine measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling. The authors sought to examine predictors of incident diabetes and improvement in cardiometabolic risk factors.

The researchers found that weight loss in the first six months was protective of diabetes (hazard ratio, 0.94 per kg; P < 0.01) and cardiometabolic risk factors (P < 0.01); however, long-term weight loss (from zero to two years) was the strongest predictor of decreased incidence of diabetes (hazard ratio, 0.90 per kg; P < 0.01) and cardiometabolic risk factor improvement (for example, fasting glucose; P < 0.01). Per participant, weight cycling ranged from zero to six times and correlated positively with incident diabetes (hazard ratio, 1.33; P < 0.01), fasting glucose (P = 0.02), homeostatic model assessment insulin resistance (P = 0.04), and systolic blood pressure (P = 0.01). The effect of weight cycling was significant for diabetes risk (hazard ratio, 1.22; P = 0.03), but not for cardiometabolic traits, after adjustment for baseline weight.

"Two-year weight loss was the strongest predictor of reduced and improvements in cardiometabolic traits," the authors write.

Pharmaceutical, nutrition, and exercise industries donated materials, equipment, or medicines and/or supported the study.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Liraglutide augments weight loss in pre-type 2 diabetes

August 15, 2013

(HealthDay)—For patients at high risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), liraglutide in additional to calorie restriction is associated with more weight loss and improvements in insulin ...

Phentermine, topiramate reduce progression to T2DM

October 21, 2013

(HealthDay)—Over two years, phentermine and topiramate extended-release (PHEN/TPM ER) treatment plus lifestyle changes lead to significant weight loss and a considerable reduction in progression to type 2 diabetes in high-risk, ...

Nonalcoholic fatty liver disease linked to CKD in T1DM

April 9, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published online April 2 in ...

Insulin resistance ups T2D risk, independent of BMI

July 7, 2014

(HealthDay)—A genetic score for insulin resistance is associated with lower body mass index (BMI) and with incident type 2 diabetes (T2D) even among individuals of normal weight, according to a study published online June ...

Recommended for you

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

'Crosstalk' gives clues to diabetes

June 15, 2015

Sometimes, listening in on a conversation can tell you a lot. For Mark Huising, an assistant professor in the Department of Neurobiology, Physiology and Behavior at the UC Davis College of Biological Sciences, that crosstalk ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.