No apparent link between sleep apnea and cancer

Illustration of obstruction of ventilation. Credit: Habib M’henni / public domain

Obstructive sleep apnea, in which people stop breathing for short periods while sleeping, affects about 5% of Canadian adults aged 45 years or older and can negatively affect health. More than 1 in 5 adult Canadians have risk factors for sleep apnea such as being overweight, being male and having diabetes, chronic nasal congestion or other health conditions.

Studies have postulated that obstructive may be linked to cancer because of low levels of oxygen in the blood.

"There is a need for a sufficiently large cohort study with a long enough follow-up to allow for the potential development of cancer that adjusts for important potential confounders, examines common cancer subtypes and has a rigorous assessment of both obstructive sleep apnea and cancer," writes Dr. Tetyana Kendzerska, Institute for Clinical Evaluative Sciences (ICES) and Women's College Hospital, University of Toronto, Toronto, Ont., with coauthors.

To understand whether obstructive sleep apnea is associated with cancer development, researchers undertook a study of 10 149 patients with the disorder who underwent a sleep study between 1994 and 2010. They linked this information to health administrative databases from 1991 to 2013. At the start of the study, 520 (5.1%) had a cancer diagnosis. In the study follow-up period (median 7.8 years), 627 (6.5%) people who did not have cancer at baseline had incident cancer. Prostate, breast, colorectal and lung cancers were the most common.

After controlling for , the researchers found no apparent causal link between obstructive sleep apnea and cancer.

"We were not able to confirm previous hypotheses that is a cause of overall through intermittent hypoxemia [low blood oxygen levels]," write the authors. "However, in subgroup analyses, we found that the level of oxygen desaturation was associated with the development of smoking-related cancer."

More information: Canadian Medical Association Journal, www.cmaj.ca/lookup/doi/10.1503/cmaj.140238

Related Stories

Osteoporosis risk heightened among sleep apnea patients

date Apr 15, 2014

A diagnosis of obstructive sleep apnea may raise the risk of osteoporosis, particularly among women or older individuals, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & ...

Sleep apnea tied to diabetes in large study

date Jun 06, 2014

In the largest study to date of the relationship between sleep apnea and diabetes, a new study of more than 8,500 Canadian patients has demonstrated a link between obstructive sleep apnea (OSA) and the development of diabetes, ...

Recommended for you

Effective sleep apnea treatment lowers diabetes risk

date Apr 27, 2015

Using a simple device for eight hours a night to treat sleep apnea can help people with prediabetes improve their blood sugar levels and may reduce the risk of progressing to diabetes, according to a new ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.