Insulin sensitivity is key renal marker in youth with T2DM

August 7, 2014
Insulin sensitivity is key renal marker in youth with T2DM

(HealthDay)—Among adolescents with type 2 diabetes, insulin sensitivity is an important marker of renal health, according to research published online July 28 in Diabetes Care.

Petter Bjornstad, M.D., of the University of Colorado in Aurora, and colleagues measured glucose infusion rate (GIR) in stratified into groups according to type 2 diabetes (46 participants), obese (29 participants), and lean (19 participants). The authors assessed the association between measured insulin sensitivity (GIR) and early markers of diabetic nephropathy as indicated by estimated glomerular filtration rate (eGFR) and measured albumin-creatinine ratio (ACR).

The researchers found that, compared with obese or lean adolescents, adolescents with type 2 diabetes had significantly lower GIR, higher eGFR, and higher ACR. About a third (34 percent) of adolescents with type 2 diabetes had albuminuria (ACR ≥30 mg/g) and 24 percent had hyperfiltration (≥135 mL/min/1.73 m²). After adjustment for age, sex, Tanner stage, , and HbA1c, adolescents with type 2 diabetes in the highest tertiles of ACR and eGFR had lower GIR than those in the mid and low tertiles (P = 0.02 and 0.04, respectively). After adjustment for sex and Tanner stage, only GIR, and not HbA1c, low-density lipoprotein cholesterol, or , was associated with eGFR (β ± SE: −2.23 ± 0.87; P = 0.02).

"To our knowledge, this report is one of the first to demonstrate an association between measured and early renal abnormalities in adolescents with type 2 diabetes," the authors write.

Explore further: Progression of dysglycemia in youth similar to adults

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Weight loss diets improve renal function in obese

June 6, 2013

(HealthDay)—Low-fat, Mediterranean, and low-carbohydrate diets are similarly effective in improving renal function in moderately obese people with or without type 2 diabetes, according to a study published online May 20 ...

Nonalcoholic fatty liver disease linked to CKD in T1DM

April 9, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published online April 2 in ...

Modifiable risk factors impact CVD mortality in T2DM

July 14, 2014

(HealthDay)—Modifiable risk factors can be targeted for early and continued intervention to reduce the risk of adverse outcomes in patients with type 2 diabetes mellitus and cardiovascular disease, according to research ...

Recommended for you

How does friendly fire happen in the pancreas?

October 21, 2016

In type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have ...

Diabetes opens floodgates to fructose

October 11, 2016

Fructose, once seen as diabetics' alternative to glucose, is fast-tracked to the liver in diabetic mice and contributes to metabolic diseases, according to new research from Harvard University.

Type 2 diabetes and obesity—what do we really know?

October 6, 2016

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.