One in six lupus patients readmitted to hospital within 30 days of discharge

August 11, 2014

A new study reveals that one in six patients with systemic lupus erythematosus (SLE) is readmitted to the hospital within 30 days of being discharged. Results published in Arthritis & Rheumatology, a journal of the American College of Rheumatology (ACR), show that black and Hispanic SLE patients were more likely to be readmitted than white patients. Readmissions among patients insured by Medicare or Medicaid were also more likely compared to patients covered by private insurance.

Lupus is a systemic, autoimmune disease where an overactive immune system attacks healthy joints and organs. Medical evidence reports that up to 25% of SLE patients require treatment in the each year, accounting for more than 140,000 hospitalizations in the U.S. Moreover, SLE has the sixth highest rate of readmission among all medical conditions in the U.S. according to a 2010 study by Elixhauser et al.

"SLE patients have one of the highest hospital readmission rates compared to those with other chronic illnesses," explains Jinoos Yazdany, M.D., M.P.H. from the Division of Rheumatology at the University of California, San Francisco. "Our study is the first large-scale examination of early readmissions following hospitalization due to SLE."

Researchers examined 55,936 hospitalizations using hospital discharge databases that included roughly 85% (810) of U.S. hospitals. The team analyzed data of 31,903 readmitted between 2008 and 2009 from 5 states – California, Florida, New York, Utah and Washington. Analyses included SLE patients 18 years of age or older who were readmitted to the hospital and excluded hospital transfers, discharges to nursing or rehabilitation facilities, maternity-related admissions or patients who died.

Results show that there were 9,244 (17%) readmissions into the hospital within 30 days of discharge. The readmissions were found among 4,916 individual SLE patients. Clinical features most associated with readmission included patients with lupus nephritis (kidney inflammation), serositis (inflammation of the lining of the lungs, heart, abdomen, or abdominal organs) and thrombocytopenia (low blood platelet count). Age was inversely related to readmission, suggesting that severe organ involvement in younger SLE may be partly to blame.

Further analyses show risk-adjusted readmission rates to be lower in New York and higher in Florida, compared to California. Hospitals with higher readmissions for SLE did not have higher admissions for other chronic conditions such as heart failure or pneumonia, which the authors believe is condition-specific to SLE readmissions and warrants further study. Dr. Yazdany concludes, "The significant geographic and hospital-level variation in readmission rates signals a need for quality improvement efforts in lupus."

Explore further: Hospital readmission rates not accurate measure of care quality

More information: "Thirty-day Hospital Readmissions in Systemic Lupus Erythematosus: Predictors and Hospital and State-level Variation." Jinoos Yazdany, Ben J. Marafino, Mitzi L. Dean, Naomi S. Bardach, Reena Duseja, Michael M. Ward and R. Adams Dudley. Arthritis & Rheumatology; Published Online: August 11, 2014. DOI: 10.1002/art.38768

Related Stories

Predictors of organ damage identified in patients with SLE

December 16, 2012

(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according to research published ...

Lupus ups risk of spontaneous subarachnoid hemorrhage

April 19, 2013

(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the April issue of Arthritis ...

Identifying targets of autoantibodies

November 25, 2013

Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...

Study identifies risk factors for hospital readmissions

June 11, 2014

Hospital readmission, an important measure of quality care, costs the United States an estimated $17 billion each year. And according to the Centers for Medicare and Medicaid Services (CMS), about half of those readmissions ...

Recommended for you

New strategy for treating arthritis discovered

November 25, 2015

Arthritis patients could one day benefit from a novel form of medicine, according to researchers at Queen Mary University of London (QMUL). Their early study indicates that arthritic cartilage, previously thought to be impenetrable ...

Team finds gene that confirms existence of psoriatic arthritis

February 5, 2015

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.