Scientists confirm effectiveness of cognitive rehabilitation in multiple sclerosis

Kessler Foundation researchers published long-term followup results of their MEMREHAB trial, which show that in individuals with MS, patterns of brain activity associated with learning were maintained at 6 months post training. The article, A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial, was published online ahead of print on June 14 by Brain Imaging and Behavior. The article appeared in the Neuroimaging and Rehabilitation Special Issue. The authors are Ekaterina Dobryakova, PhD, Glenn Wylie, DPhil, John DeLuca, PhD, and Nancy Chiaravalloti, PhD, of Kessler Foundation.

This pilot study was based on the Foundation's MEMREHAB Trial, which provided the first Class I evidence for the efficacy of cognitive rehabilitation in MS. (Chiaravalloti N, et al: An RCT to treat in MS. Neurology 2013(81) doi: 10.1212/01.wnl.0000437295.97946.a8S), was released as an epub ahead of print on November 8. The 10-session memory retraining protocol used in the MEMREHAB study was the modified Story Memory Technique (mSMT).

For the , participants underwent evaluation of memory performance and at baseline, immediately following memory retraining, and at 6-month followup. Results showed that the patterns of increased cerebral activation that correlated with learning were maintained at 6-month followup. "These results support the long-term effectiveness of in individuals with cognitive impairment caused by MS," said Nancy Chiaravalloti, PhD, director of Neuroscience & Neuropsychology and Traumatic Brain Injury (TBI) Research at Kessler Foundation."For optimal care, it is crucial for clinicians who care for this population to become familiar with the mSMT protocol."

The mSMT protocol has been translated into Spanish and is being used in the U.S., Mexico, and Argentina. A Chinese translation has also been completed for use in upcoming studies. The protocol is currently being tested in the population with caused by TBI.

More information: DOI: 10.1007/s11682-014-9309-9

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

The brain treats real and imaginary objects in the same way

8 hours ago

The human brain can select relevant objects from a flood of information and edit out what is irrelevant. It also knows which parts belong to a whole. If, for example, we direct our attention to the doors of a house, the brain ...

Research suggests brain's melatonin may trigger sleep

10 hours ago

If you walk into your local drug store and ask for a supplement to help you sleep, you might be directed to a bottle labeled "melatonin." The hormone supplement's use as a sleep aid is supported by anecdotal ...

New understanding of stroke damage may aid recovery

10 hours ago

Stroke can lead to a wide range of problems such as depression and difficulty moving, speaking and paying attention. Scientists have thought these issues were caused by damage to the brain's "computer processors"—cells ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.