Tumor blood vessel protein provides potential therapeutic target

Tumor blood vessels supply oxygen and nutrients to cancer cells and provide access to other organs. While tumor vasculature shares many features with normal vessels, their unique characteristics are potential therapeutic targets.

A recent study in the Journal of Clinical Investigation identifies a tumor vessel-specific protein, L1 that can be targeted to reduce .

Using a mouse pancreatic cancer model, Ugo Cavallaro and colleagues at the European Institute of Oncology found that loss of L1 reduced tumor blood vessel formation, which inhibited growth and metastasis. In patients with pancreatic cancer, L1 was present within and not in vessels of healthy tissue.

The results from this study suggest that targeting L1 has potential as a cancer-limiting strategy.

More information: Endothelial deficiency of the adhesion molecule L1 reduces tumor angiogenesis and promotes vessel normalization, J Clin Invest. DOI: 10.1172/JCI70683

Related Stories

Recommended for you

New strategies against rare, fatal lung syndrome

date 3 hours ago

Hermansky-Pudlak syndrome (HPS) patients suffer symptoms including albinism, visual impairment, and slow blood clotting, but what makes some versions of the genetic condition fatal is that patients with some ...

How a newborn baby sees you

date 11 hours ago

A newborn infant can see its parents' expressions at a distance of 30 cm. For the first time researchers have managed to reconstruct infants visual perception of the world.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.