Tumor blood vessel protein provides potential therapeutic target

Tumor blood vessels supply oxygen and nutrients to cancer cells and provide access to other organs. While tumor vasculature shares many features with normal vessels, their unique characteristics are potential therapeutic targets.

A recent study in the Journal of Clinical Investigation identifies a tumor vessel-specific protein, L1 that can be targeted to reduce .

Using a mouse pancreatic cancer model, Ugo Cavallaro and colleagues at the European Institute of Oncology found that loss of L1 reduced tumor blood vessel formation, which inhibited growth and metastasis. In patients with pancreatic cancer, L1 was present within and not in vessels of healthy tissue.

The results from this study suggest that targeting L1 has potential as a cancer-limiting strategy.

More information: Endothelial deficiency of the adhesion molecule L1 reduces tumor angiogenesis and promotes vessel normalization, J Clin Invest. DOI: 10.1172/JCI70683

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Testing time for stem cells

2 hours ago

DefiniGEN is one of the first commercial opportunities to arise from Cambridge's expertise in stem cell research. Here, we look at some of the fundamental research that enables it to supply liver and pancreatic ...

Team finds key signaling pathway in cause of preeclampsia

21 hours ago

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause ...

Rapid test to diagnose severe sepsis

Oct 23, 2014

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.

User comments