Study reveals potential therapy targets for triple-negative breast cancer

January 11, 2016
Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia

In cancer, cell signaling pathways are the critical chain of events that can either quash or quicken disease progression.

A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer Center has revealed new information about how molecules called long non-coding RNAs (lncRNA) interact with HIF-1, a signaling pathway that is overexpressed in many cancers. HIF-1 has been shown to regulate breast progression.

The team's findings, published online in today's Nature Cell Biology, explored HIF-1's role in (TNBC), an aggressive and hard-to-treat form of the disease. The study analyzed data from The Cancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cancer.

"Triple-negative continues to be a severe health problem, demanding the consideration of emerging long non-coding RNAs as biomarkers and therapeutic targets in combatting this disease," said Liquing Yang, Ph.D., assistant professor in the Department of Molecular & Cellular Oncology.

Yang and co-author Chunru Lin, Ph.D., an assistant professor in the same department, confirmed four sites for phosphorylation, a process that turns protein enzymes off and on, impacting key cellular functions.

"Our study identified four previously unknown phosphorylation sites in a LINK-A regulated signaling pathway," said Lin. "These events predict a worse outcome in TNBC patients suggesting that the LINK-A pathway plays a critical role in this disease and may provide wide-ranging therapeutic treatment targets."

The team identified an lncRNA known as LINK-A, that activates HIF1 signaling in triple-negative breast cancer.

"Our study delineates an lncRNA-protein kinase module that regulates HIF1," said Yang. "The LINK-A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK-A and LINK-A interacting kinases and receptors as promising therapeutic targets for TNBC."

Explore further: Discovery may help breast cancer treatment

More information: The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer, DOI: 10.1038/ncb3295

Related Stories

Discovery may help breast cancer treatment

November 7, 2014

Researchers led by Dr. Debra Auguste, associate professor, biomedical engineering, in the Grove School of Engineering at The City College of New York, have identified a molecule that could lead to developing treatment for ...

Recommended for you

Oxygen can impair cancer immunotherapy in mice

August 25, 2016

Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.