Agency for Science, Technology and Research (A*STAR), Singapore
Protein that represses critical checkpoint protein for cellular growth helps drive tumor development
(Medical Xpress)—One of the hallmarks of cancer is unchecked cellular growth. Fortunately, our cells contain a number of tumor suppressor proteins, including the cell cycle regulator p21, to keep cell growth ...
Cancer
Feb 13, 2013 |
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Novel microscale epigenomics technology: Possible to study the epigenome of rare cell populations and biopsy samples
Scientists at A*STAR's Genome Institute of Singapore (GIS) have successfully developed a method to map the epigenome using 100 times fewer cells than was previously possible. The discovery, published in the journal Developmental Ce ...
Genetics
Feb 11, 2013 |
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DNA analysis reveals genetic variants that make individuals susceptible to form of glaucoma prevalent in Asian countries
Glaucoma is the leading cause of irreversible blindness in the world. A form known as primary open angle glaucoma (POAG) predominantly affects Europeans and Africans, whereas primary closed angle glaucoma ...
Genetics
Jan 30, 2013 |
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New design guidelines simplify development of targeted therapies for muscular dystrophy and other diseases
The dystrophin protein offers critical support to muscle fibers. Mutations affecting dystrophin's expression cause the muscle-wasting disease muscular dystrophy. In Duchenne muscular dystrophy (DMD), these ...
Genetics
Jan 30, 2013 |
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Researchers identify four distinct mechanisms that contribute to gastric cancers
Scientists at A*STAR's Genome Institute of Singapore (GIS) headed a study that discovered four processes by which gastric cancer is formed. This is extremely important since gastric cancer is the second most common cause ...
Cancer
Jan 28, 2013 |
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Singapore scientists discover genes responsible for cornea blindness
Scientists at Singapore Eye Research Institute and A*STAR's Genome Institute of Singapore have succeeded in identifying genes for central corneal thickness that may cause potentially blinding eye conditions. These eye conditions ...
Genetics
Jan 16, 2013 |
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Cancer biology: Keeping bad company
The p53 tumor suppressor protein manages DNA repair mechanisms in response to genetic damage and kills off precancerous cells before they multiply. The loss of p53 due to mutation greatly increases risk of ...
Cancer
Jan 16, 2013 |
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Cerebral malaria: Pinpointing a potential therapeutic target
An excessive response of the immune system to malarial infection can lead to serious complications, such as cerebral malaria. While the mechanism causing the onset of cerebral malaria is unclear, immunologists ...
Immunology
Jan 16, 2013 |
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Computer simulations of blood flow through mechanical heart valves could pave the way for more individualized prosthetic
Every year, over 300,000 heart valve replacement operations are performed worldwide. Diseased valves are often replaced with mechanical heart valves (MHVs), which cannot yet be designed to suit each patient's ...
Cardiology
Dec 19, 2012 |
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Ability to chart the molecular progress of diabetes brings personalized medicine closer to realization
Researchers in Singapore have succeeded in tracking, for the first time, the molecular changes caused by type 2 diabetes that affect how the body handles glucose production in the liver. In a series of experiments ...
Diabetes
Dec 19, 2012 |
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Scientists identify new biomarker for cancer in bone marrow: Promise for patients of multiple myeloma
Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow. Patients with this form of cancer usually do not ...
Cancer
Dec 13, 2012 |
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A study of fruit fly genes reveals how molecules cooperate to induce tumor formation
Cancer biologists have known for decades that even the most potent cancer-causing genes do not act alone. Yet, identifying which combinations of genetic changes can cause a tumor to form and disease to progress ...
Genetics
Dec 05, 2012 |
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Scientists identify potential drug target for inflammatory diseases including cancers
A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune ...
Inflammatory disorders
Nov 21, 2012 |
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How defects in a signaling protein sabotage the immune system in multiple, seemingly contradictory ways
The antibody response to immune threats is managed by cells known as B lymphocytes. The differentiation and function of B cells are tightly regulated to ensure a prompt response to confirmed dangers, such ...
Immunology
Nov 21, 2012 |
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Recently discovered stem cell population could one day provide useful source material for kidney repair
Within every human kidney, millions of filtration units known as nephrons are hard at work clearing metabolic waste products from the blood. Given the dirty work they perform, one might expect that the cells ...
Medical research
Nov 07, 2012 |
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