Agency for Science, Technology and Research (A*STAR), Singapore
First influenza vaccine brought to clinical testing
Singapore's Agency for Science, Technology and Research (A*STAR) and Switzerland's Cytos Biotechnology AG today announced that the first healthy volunteer has been dosed in a Phase 1 clinical trial with their ...
Medications
May 17, 2013 |
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Singapore scientists find genes associated with glaucoma
Singapore scientists have identified three new genes associated with Primary Angle Closure Glaucoma (PACG), a leading cause of blindness in Chinese people. PACG affects 15 million people worldwide, 80% of whom live in Asia.
Genetics
Sep 03, 2012 |
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How connections in the brain must change to form memories could help to develop artificial cognitive computers
Exactly how memories are stored and accessed in the brain is unclear. Neuroscientists, however, do know that a primitive structure buried in the center of the brain, called the hippocampus, is a pivotal region ...
Neuroscience
Nov 07, 2012 |
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Computer program identifies rare mutations harbored within diverse populations of cancer cells and microorganisms
A tumor is not a uniform mass of identical cells. However, teasing apart genetic heterogeneity within a biopsied tumor can be difficult. Researchers often fail to tell the difference between a rare variant ...
Cancer
Apr 24, 2013 |
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Identification of specific genetic variants associated with common eye disorders could improve treatment and prevention
The eye is covered by a clear and protective layer called the cornea, and abnormal thickness of the cornea can result in eye disease. An international research team including Chiea Chuen Khor of the A*STAR ...
Genetics
Apr 24, 2013 |
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Understanding abnormal proteins in degenerative diseases
Amyloids, or fibrous aggregates of abnormally folded proteins, are a common feature in degenerative diseases such as Alzheimer's, diabetes and cancer. Amyloids occur naturally in the body, but despite decades ...
Medical research
Apr 22, 2013 |
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Singapore scientists discover genes responsible for cornea blindness
Scientists at Singapore Eye Research Institute and A*STAR's Genome Institute of Singapore have succeeded in identifying genes for central corneal thickness that may cause potentially blinding eye conditions. These eye conditions ...
Genetics
Jan 16, 2013 |
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Scientists unravel mechanism that causes liver cancer
Scientists at the Genome Institute of Singapore (GIS) have unraveled the mechanism that causes liver cancer (hepatocellular carcinoma, HCC), one of the most common solid tumors worldwide. This genome-wide research was done ...
Genetics
May 28, 2012 |
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Groundbreaking discovery of mutation causing genetic disorder in humans
Scientists at A*STAR’s Institute of Medical Biology (IMB), in collaboration with doctors and scientists in Jordan, Turkey, Switzerland and USA, have identified the genetic cause of a birth defect known as Hamamy syndrome. ...
Genetics
May 14, 2012 |
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Potential drug for treating deadly brain cancer
(Medical Xpress)—A*STAR scientists have identified a biomarker of the most lethal form of brain tumours in adults − glioblastoma multiforme. The scientists found that by targeting this biomarker and depleting ...
Cancer
Sep 04, 2012 |
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Exposure to hepatitis B virus activates immunity in young people, suggesting benefits for earlier treatment
Infectious disease experts have long thought that children, teenagers and young adults who are chronically infected with the hepatitis B virus (HBV) lack the immune cells needed to fight this pathogen. As ...
Diseases, Conditions, Syndromes
Feb 27, 2013 |
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Bonanza of genomic sequence data gives researchers valuable new insights into a poorly understood cancer
Stomach cancer doesn't get the same publicity as lung or breast cancer, but it is a health threat to be taken very seriously. "Gastric cancer is the second leading cause of worldwide cancer mortality, with ...
Genetics
Sep 12, 2012 |
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Protein implicated in lupus promotes disease progression by distinct mechanisms in different immune cells
Patients with systemic lupus erythematosus (SLE) come under attack by their immune system, producing 'autoantibodies' that inflict damage throughout the body. Antibodies normally target foreign proteins, ...
Immunology
Mar 13, 2013 |
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Earlier treatment for young patients with chronic hepatitis B more effective in clearing virus
Scientists from A*STAR's Singapore Institute for Clinical Sciences (SICS), together with clinical collaborators from London , discovered for the first time that children and young patients with chronic Hepatitis B Virus infection ...
Diseases, Conditions, Syndromes
Sep 06, 2012 |
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Novel microscale epigenomics technology: Possible to study the epigenome of rare cell populations and biopsy samples
Scientists at A*STAR's Genome Institute of Singapore (GIS) have successfully developed a method to map the epigenome using 100 times fewer cells than was previously possible. The discovery, published in the journal Developmental Ce ...
Genetics
Feb 11, 2013 |
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