American Association for Cancer Research
Noninvasive measurement enables use of IFP as potential biomarker for tumor aggressiveness
Researchers validated a method of noninvasive imaging that provides valuable information about interstitial fluid pressure of solid tumors and may aid in the identification of aggressive tumors, according to the results of ...
Cancer
Oct 01, 2012 |
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Model confirms active surveillance as viable option for men with low-risk prostate cancer
A new research model has estimated that the difference in prostate cancer mortality among men with low-risk disease who choose active surveillance versus those who choose immediate treatment with radical prostatectomy is ...
Cancer
Sep 24, 2012 |
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Denosumab reduces burden of giant-cell tumor of the bone
Treatment with denosumab, a drug targeted against a protein that helps promote bone destruction, decreased the number of tumor giant cells in patients with giant-cell tumor of the bone, and increased new bone formation, according ...
Cancer
Sep 21, 2012 |
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PARP inhibitors may have clinical utility in HER2-positive breast cancers
Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive ...
Cancer
Sep 17, 2012 |
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Novel therapeutic targets identified for small cell lung cancer
Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the ...
Cancer
Sep 06, 2012 |
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Researchers identified markers that predict progression of oral lesions to cancer
A group of molecular markers have been identified that can help clinicians determine which patients with low-grade oral premalignant lesions are at high risk for progression to oral cancer, according to data from the Oral ...
Cancer
Aug 21, 2012 |
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Mechanisms of acquired chemoresistance in ovarian cancer identified
The presence of multiple ovarian cancer genomes in an individual patient and the absence or downregulation of the gene LRP1B are associated with the development of chemoresistance in women with the high-grade serous cancer ...
Cancer
Aug 15, 2012 |
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Denosumab superior to zoledronic acid for breast cancer patients with bone metastases
Treatment with denosumab resulted in a greater reduction in skeletal-related events in patients with breast cancer that spread to the bones compared with zoledronic acid, while also maintaining health-related quality of life, ...
Cancer
Aug 14, 2012 |
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TRPM7 protein key to breast cancer metastasis in animal models
The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Ca ...
Cancer
Aug 07, 2012 |
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Immune responses can be generated locally within human melanoma skin metastases
In many types of cancer, activated immune cells infiltrate the tumor and influence clinical outcome. It is not always clear where these cells are activated, but results reported in Cancer Research, a journal of the Americ ...
Cancer
Jul 31, 2012 |
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Researchers identify potential treatment target for metastatic pancreatic cancer using CTC chip technology
(Medical Xpress) -- Researchers with the Stand Up To Cancer CTC Chip Dream Team have identified a potential treatment target in metastatic pancreatic cancer through a detailed analysis of genes expressed in circulating tumor ...
Cancer
Jul 30, 2012 |
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Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
Inhibitors of indoleamine 2,3-dioxygenase (IDO) are being assessed in clinical trials as a potential treatment for recurrent or refractory solid tumors. Clear genetic rationale for these trials, together with evidence that ...
Cancer
Jul 19, 2012 |
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Coffee consumption inversely associated with risk of most common form of skin cancer
Increasing the number of cups of caffeinated coffee you drink could lower your risk of developing the most common form of skin cancer, basal cell carcinoma, according to a study published in Cancer Research, a jour ...
Cancer
Jul 02, 2012 |
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Novel chemotherapy agent appears to be a promising pancreatic cancer treatment
A novel chemotherapeutic agent, the highly selective MEK1/2 inhibitor BAY 86-9766, may be a promising future treatment for pancreatic ductal adenocarcinoma (PDAC), according to preclinical results presented at the American ...
Cancer
Jun 20, 2012 |
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High-fat/calorie diet accelerates development of pancreatic cancer
Study results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21, strongly suggest that a diet high in fat and calories can hasten the development ...
Cancer
Jun 20, 2012 |
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