American Association for Cancer Research
Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines
Results of some preclinical trials have shown that low doses of the antidiabetic drug metformin may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because ...
Cancer
Jun 19, 2012 |
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Adding erlotinib to bevacizumab/chemoradiotherapy regimen for pancreatic cancer safe, tolerable
The addition of high doses of erlotinib to the treatment regimen of bevacizumab and capecitabine with radiotherapy seems to benefit patients with locally advanced pancreatic cancer, according to results of a phase I study ...
Cancer
Jun 19, 2012 |
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Biomarker panel to screen for pancreatic cancer may be possible
The development of a highly accurate, blood-based pancreatic adenocarcinoma screen that would be accurate enough to test the general population for this deadly disease may not be far out of reach, according to data presented ...
Cancer
Jun 19, 2012 |
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Leukemia inhibitory factor may be a promising target against pancreatic cancer
Pancreatic cancer is one of the deadliest forms of cancer, defying most treatments. Its ability to evade therapy may be attributable to the presence of cancer stem cells, a subset of cancer cells present in pancreatic tumors ...
Cancer
Jun 19, 2012 |
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A combination of TH-302 and radiation reduced human pancreatic tumor growth in hypoxic xenografts
A combination of the prodrug TH-302 and radiation may provide an effective treatment strategy for pancreatic cancer, according to preclinical results presented at the American Association for Cancer Research's Pancreatic ...
Cancer
Jun 19, 2012 |
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Genetic marker in vitamin D receptor gene associated with increased pancreatic cancer survival
Pancreatic cancer patients with a genetic marker linked to increased expression of the receptor for vitamin D have higher rates of overall survival, according to findings presented at the American Association for Cancer Research's ...
Cancer
Jun 19, 2012 |
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Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
Combining a new targeted therapy with standard chemotherapy may help defeat pancreatic cancer, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, ...
Cancer
Jun 19, 2012 |
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RLIP76 contributes to pancreatic cancer cell resistance to chemotherapy and radiation
Researchers at the City of Hope Comprehensive Cancer Center have not only identified a protein that allows pancreatic cancer cells to resist therapy but also developed a way to block it, according to results presented at ...
Cancer
Jun 19, 2012 |
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Nerve growth factors elevated in pancreatic cancer model
Severe pain is a major symptom of pancreatic cancer. The results of a new study show that four different factors involved in the growth and maintenance of nerves are elevated in a mouse model of pancreatic cancer. This is ...
Cancer
Jun 19, 2012 |
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Abnormal gene product associated with prostate cancer generated by unusual mechanism
Researchers have identified a potential new pathway in prostate cancer cells by which cancer-driving gene products can be generated, according to a study published in Cancer Discovery, a journal of the American Association for Ca ...
Cancer
Jun 19, 2012 |
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Sun exposure and sun-sensitive skin type decreased risk for pancreatic cancer
High levels of ultraviolet radiation at an individual's birth location, sun-sensitive skin type and a history of skin cancer each decreased risk for pancreatic cancer, according to study results presented at the American ...
Cancer
Jun 19, 2012 |
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Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, a jour ...
Cancer
Jun 15, 2012 |
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Clinical trial design supports original accelerated approval of sunitinib for GIST
Patients benefitted from an important design element in the pivotal phase III clinical trial that led to Food and Drug Administration and worldwide regulatory approval of sunitinib for the treatment of gastrointestinal stromal ...
Cancer
Jun 01, 2012 |
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Weight loss led to reduction in inflammation
Postmenopausal women who were overweight or obese and lost at least 5 percent of their body weight had a measurable reduction in markers of inflammation, according to a study published in Cancer Research, a journal of the ...
Cancer
May 01, 2012 |
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KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
Testing patients with non-small cell lung cancer for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the updated results of a preclinical ...
Cancer
Apr 04, 2012 |
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