American Association for Cancer Research
Sleep problems may increase risk for prostate cancer
Men who reported sleep problems, including difficulty falling asleep and staying asleep, had up to a twofold increased risk for prostate cancer, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a jour ...
Cancer
May 07, 2013 |
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Exercise-related changes in estrogen metabolism may lower breast cancer risk
Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a jour ...
Cancer
May 07, 2013 |
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Women smokers may have greater risk for colon cancer than men
Smoking increased the risk for developing colon cancer, and female smokers may have a greater risk than male smokers, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Associ ...
Cancer
Apr 30, 2013 |
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Engineered antibody demonstrated safety, efficacy in wide range of advanced tumors
(Medical Xpress)—The engineered antibody MPDL3280A, which targets a protein called programmed death-ligand 1 (PD-L1), was safe and effective for several cancers, according to phase I study results presented at the AACR ...
Cancer
Apr 10, 2013 |
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New approach evaluates effect of physical activity on estrogen metabolism in postmenopausal women
Researchers have generated new insights into the ways in which physical activity affects how much estrogen is broken down and secreted in the urine of postmenopausal women. These findings enhance understanding of the potential ...
Cancer
Apr 10, 2013 |
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AACR releases policy guidance on tobacco and cancer clinical trials
An American Association for Cancer Research (AACR) statement calls on the oncology community to provide evidence-based tobacco cessation treatment for all cancer and cancer-screening patients and to evaluate tobacco as a ...
Cancer
Apr 10, 2013 |
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Prevalence of benign disease diagnosis after lung surgery varied widely by state
Benign disease diagnosis rates after surgery for suspected lung cancer varied widely by state, and the reasons for these variations could inform health policy and clinical guidelines for lung cancer screening, according to ...
Cancer
Apr 10, 2013 |
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Cohort study indicates that selenium may be protective against advanced prostate cancer
A greater level of toenail selenium was associated with a significant decrease in the risk for advanced prostate cancer, according to data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10.
Cancer
Apr 10, 2013 |
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Patients with BRCA1 mutations, but not BRCA2 mutations, had poorer prognosis compared with noncarriers
Patients with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found ...
Cancer
Apr 09, 2013 |
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Some melanoma survivors still use tanning beds, skip sunscreen
Although most survivors of melanoma take precautions to protect their skin from the sun and further occurrences of cancer, data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10, revealed that ...
Cancer
Apr 09, 2013 |
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Novel AKT pathway inhibitor, ARQ 092, demonstrated safety, effective target inhibition
Researchers have confirmed that the novel oral agent ARQ 092 inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumors, according to phase I data presented at the AACR ...
Cancer
Apr 09, 2013 |
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Intermittent treatment with vemurafenib may prevent lethal drug resistance in melanoma
Vemurafenib-resistant tumors in patients with melanoma showed reduced growth after cessation of treatment, and in animal models, drug resistance was prevented by intermittent treatment, according to data presented at the ...
Cancer
Apr 08, 2013 |
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Biomarkers discovered that may help predict response to drugs targeting KRAS-mutated NSCLC
Scientists have identified biomarkers that may help predict whether patients with KRAS-mutated non-small cell lung cancer (NSCLC) will respond to concurrent treatment with an MEK inhibitor and a PI3 kinase inhibitor, a drug ...
Cancer
Apr 08, 2013 |
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Preclinical study indicates potential for novel inhibitor to overcome drug resistance induced by RAF, MEK inhibitors
A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, ...
Cancer
Apr 08, 2013 |
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AKT inhibitor AZD5363 well tolerated, yielded partial response in patients with advanced solid tumors
The investigational drug AZD5363, which has shown activity in preclinical studies, was well tolerated in humans, and two patients with advanced solid tumors showed partial response, according to data presented at the AACR ...
Cancer
Apr 08, 2013 |
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