Children's Hospital Boston

Oncology & Cancer

How a leukemia hijacks the genes needed by blood stem cells

As a child, Lynn Aureli didn't know that a particular genetic change contributed to her acute myeloid leukemia (AML)—an alteration that eventually would help explain the cancer's lack of response to chemotherapy. Nor was ...

Oncology & Cancer

Earlier detection of a malignancy in neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3,000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer. Diagnosing malignant peripheral nerve ...

Diseases, Conditions, Syndromes

Understanding brief resolved unexplained events in infants

Brief resolved unexplained events (BRUEs) are episodes marked by concerning changes in breathing, consciousness, muscle tone, and skin color (cyanosis or paleness). They tend to occur in previously healthy infants and send ...

Surgery

AI could change the way clinicians look at hip preservation

Orthopedic surgeons and biomedical engineers are trained to approach adolescent and young adult hip pain from two different perspectives. Surgeons typically look at conditions such as femoroacetabular impingement (FAI) and ...

Oncology & Cancer

Obesity is increasing people's risk of cancer. Why?

Obesity is now a global epidemic, and it is increasing people's risk for cancer. The National Cancer Institute lists more than a dozen cancers that are associated with overweight and obesity. But how obesity increases cancer ...

Genetics

Chromosomal testing expands options for exploring causes of SIDS

A genetic test known as chromosomal microarray analysis (CMA) could help identify the cause of sudden infant death syndrome (SIDS) or its counterpart in older children, known as sudden unexplained death in childhood (SUDC), ...

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