Children's Hospital of Philadelphia
The Children's Hospital of Philadelphia, (CHOP) was founded in 1855 and is the oldest children's hospital in the United States. CHOP is consistently rated as the best children's hospital in the U.S. CHOP has lead many breakthroughs in pediatric treatment and medical research. CHOP is served by Penn's School of Medicine. Currently, CHOP is pursuing numerous clinical trials and has embarked on a massive study of DNA and its relation to childhood disease and prevention. The Center for Applied Genomics is part of CHOP medical research.
Philadelphia, PA 19104-4399
Turning human stem cells into brain cells sheds light on neural development
Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system ...
Medical research
May 02, 2013 |
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Rear seat design: A priority for children's safety in cars
A research report released today from The Children's Hospital of Philadelphia (CHOP) provides specific recommendations for optimizing the rear seat of passenger vehicles to better protect its most common ...
Health
Apr 29, 2013 |
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Scripts help novice instructors teach pediatric CPR
New, low-tech teaching techniques used by novice instructors may improve training for healthcare providers in performing cardiopulmonary resuscitation (CPR) on children who suffer cardiac arrest. Researchers ...
Pediatrics
Apr 24, 2013 |
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National teen driving report finds safety gains for teen passengers
A new report on teen driver safety released today by The Children's Hospital of Philadelphia (CHOP) and State Farm shows encouraging trends among teen passengers. In 2011 more than half of teen passengers ...
Health
Apr 04, 2013 |
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Details of gene pathways suggest fine-tuning drugs for child brain tumors
Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists ...
Cancer
Mar 26, 2013 |
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Abnormal growth regulation may occur in children with heart defects
The poor growth seen in children born with complex heart defects may result from factors beyond deficient nutrition. A new study by pediatric researchers suggests that abnormalities in overall growth regulation play a role.
Pediatrics
Feb 19, 2013 |
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Gene variants found to affect human lifespan
By broadly comparing the DNA of children to that of elderly people, gene researchers have identified gene variants that influence lifespan, either by raising disease risk or by providing protection from disease.
Genetics
Feb 04, 2013 |
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Scientists create one-step gene test for mitochondrial diseases
More powerful gene-sequencing tools have increasingly been uncovering disease secrets in DNA within the cell nucleus. Now a research team is expanding those rapid next-generation sequencing tests to analyze a separate source ...
Medical research
Jan 29, 2013 |
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Novel gene-searching software improves accuracy in disease studies
A novel software tool, developed at The Children's Hospital of Philadelphia, streamlines the detection of disease-causing genetic changes through more sensitive detection methods and by automatically correcting for variations ...
Genetics
Jan 22, 2013 |
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Longer CPR extends survival in both children and adults
Experts from The Children's Hospital of Philadelphia were among the leaders of two large national studies showing that extending CPR longer than previously thought useful saves lives in both children and adults. The research ...
Cardiology
Jan 21, 2013 |
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Tumors evolve rapidly in a childhood cancer, leaving fewer obvious tumor targets
An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene ...
Genetics
Jan 20, 2013 |
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25 new autism-related gene variants discovered
Genetics researchers have identified 25 additional copy number variations (CNVs)—missing or duplicated stretches of DNA—that occur in some patients with autism. These CNVs, say the researchers, are "high impact": although ...
Genetics
Jan 14, 2013 |
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Home visiting program for first-time moms may be struggling to reduce serious injuries to children
New research from PolicyLab at The Children's Hospital of Philadelphia shows that one of the nation's largest programs providing home visitation support for at-risk mothers and children may not be as successful in reducing ...
Health
Dec 12, 2012 |
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Engineered immune cells produce complete response in child with an aggressive pediatric leukemia
By reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed ...
Cancer
Dec 09, 2012 |
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Genes linked to low birth weight, adult shortness and later diabetes risk
An international team of genetics researchers has discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, and appear to affect longer-term outcomes such as ...
Genetics
Dec 02, 2012 |
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