Children's Hospital of Philadelphia
Largest-ever genome-wide study identifies genes for common childhood obesity
Genetics researchers have identified at least two new gene variants that increase the risk of common childhood obesity.
Genetics
Apr 08, 2012 |
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Genes linked to low birth weight, adult shortness and later diabetes risk
An international team of genetics researchers has discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, and appear to affect longer-term outcomes such as ...
Genetics
Dec 02, 2012 |
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Turning human stem cells into brain cells sheds light on neural development
Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system ...
Medical research
May 02, 2013 |
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Tumors evolve rapidly in a childhood cancer, leaving fewer obvious tumor targets
An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene ...
Genetics
Jan 20, 2013 |
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New gene variants raise risk of neuroblastoma, influence tumor progression
Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens ...
Genetics
Sep 04, 2012 |
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25 new autism-related gene variants discovered
Genetics researchers have identified 25 additional copy number variations (CNVs)—missing or duplicated stretches of DNA—that occur in some patients with autism. These CNVs, say the researchers, are "high impact": although ...
Genetics
Jan 14, 2013 |
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Cornelia deLange syndrome: Mutations disrupt cellular recycling and cause childhood genetic disease
Genetics researchers have identified a key gene that, when mutated, causes the rare multisystem disorder Cornelia deLange syndrome (CdLS). By revealing how mutations in the HDAC8 gene disrupt the biology of proteins that ...
Genetics
Aug 12, 2012 |
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Details of gene pathways suggest fine-tuning drugs for child brain tumors
Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists ...
Cancer
Mar 26, 2013 |
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Large meta-analysis finds new genes for type 1 diabetes
The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene ...
Genetics
Sep 29, 2011 |
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Rear seat design: A priority for children's safety in cars
A research report released today from The Children's Hospital of Philadelphia (CHOP) provides specific recommendations for optimizing the rear seat of passenger vehicles to better protect its most common ...
Health
Apr 29, 2013 |
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Bioengineered protein shows preliminary promise as new therapy for hemophilia
A genetically engineered clotting factor that controlled hemophilia in an animal study offers a novel potential treatment for human hemophilia and a broad range of other bleeding problems.
Genetics
Oct 23, 2011 |
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New gene study of ADHD points to defects in brain signaling pathways
Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signaling pathways. The study raises the possibility ...
Attention deficit disorders
Dec 04, 2011 |
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Scripts help novice instructors teach pediatric CPR
New, low-tech teaching techniques used by novice instructors may improve training for healthcare providers in performing cardiopulmonary resuscitation (CPR) on children who suffer cardiac arrest. Researchers ...
Pediatrics
Apr 24, 2013 |
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Basic biology offers clues to better neuroblastoma treatments
By studying tumor biology at the molecular level, researchers are gaining a deeper understanding of drug resistance -- and how to avoid it by designing pediatric cancer treatments tailored to specific mutations in a child's ...
Cancer
Nov 09, 2011 |
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Gene variants found to affect human lifespan
By broadly comparing the DNA of children to that of elderly people, gene researchers have identified gene variants that influence lifespan, either by raising disease risk or by providing protection from disease.
Genetics
Feb 04, 2013 |
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