Cincinnati Children's Hospital Medical Center

Neuroscience

Study suggests genetic reason for impaired skilled movements

Scientists report in Neuron the lost function of two genes prevents infant laboratory mice from developing motor skills as they mature into adults. Researchers also suggest in their study that people with certain motor development ...

Neuroscience

HIPPO's molecular balancing act helps nerves not short circuit

Scientists write in Nature Communications it may be possible to therapeutically fine tune a constantly shifting balance of molecular signals to ensure the body's peripheral nerves are properly insulated and functioning normally. ...

Inflammatory disorders

Experimental drug targets nucleus of allergen-sensitized cells

Transcription factors, the tiny proteins that switch genes on or off in the nucleus of cells, are considered unreachable molecular targets for drugs attempting to treat medical conditions. Overcoming this challenge, researchers ...

Immunology

Nature study suggests new therapy for Gaucher disease

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies.

Medical research

Scientists tissue engineer human intestines and functioning nerves

Scientists report in Nature Medicine using human pluripotent stem cells to grow human intestinal tissues that have functioning nerves in a laboratory, and then using these to recreate and study a severe intestinal nerve disorder ...

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